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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Supplementation of alpha-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes

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Gomes, Patricia M. [1] ; Hollanda-Miranda, Wallace R. [1] ; Beraldo, Rebeca A. [1] ; Castro, Ana V. B. [1] ; Geloneze, Bruno [2] ; Foss, Milton C. [1] ; Foss-Freitas, Maria C. [1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Endocrinol & Metab, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Lab Invest Metab & Diabet, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRITION; v. 31, n. 6, p. 853-857, JUN 2015.
Web of Science Citations: 15

Objective: omega-3 Polyunsaturated a-linolenic acid (ALA) supplementation has not been studied in the setting of adiponectin levels and insulin sensitivity (IS) improvements in patients with type 2 diabetes mellitus (T2DM) by hyperinsulinemic-euglycemic clamp (HEC). The aim of this study was to examine the influence of w-3 ALA on IS and adiponectin. Methods: We conducted a randomized study in patients with T2DM and assessed IS using HEC. Twenty patients with T2DM were included and randomly assigned to receive 3 g/d of ALA or placebo for 60 d, in a double-blind design. The assessment of IS by HEC was performed at baseline and after 60 d in all patients; blood samples were taken for the measurement of serum lipids, glucose, insulin, adiponectin, and cytokines. The primary outcome variables were an increase of both glucose infusion rate (GIR) in steady state and glucose metabolization (M) by HEC. The secondary outcomes were an increase in adiponectin levels and a decrease in fasting plasma glucose, glycated hemoglobin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipids and cytokines. The study was conducted at an academic medical center. Results: The ALA group improved IS corrected for fat-free mass (M/FFM; P = 0.04). Both groups showed increased adiponectin after 60 d (P = 0.01), however, the increase for the ALA group was greater (P = 0.04). In the ALA group, adiponectin was positively correlated with GIR (r = 0.76; P= 0.01) and M/FFM (r = 0.62; P = 0.06), and negatively correlated with HOMA-IR (r = 0.61; P = 0.03). Conclusion: omega-3 ALA supplementation improved glucose homeostasis and was associated with an increase in adiponectin. Improvement in the overall metabolic profile with omega-3 ALA suggests a potential clinical utility for this agent and requires further investigation. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/09640-7 - Metabolic effects of omega-3 fatty acid in insulin resistance conditions
Grantee:Maria Cristina Foss de Freitas
Support Opportunities: Research Grants - Young Investigators Grants