Borim, M. P.
Liberatore, Jr., R. D. R.
Pires, A. C.
Dias, M. A. F.
Brandao de Mattos, C. C.
de Mattos, L. C.
Total Authors: 7
 FAMERP, Fac Med Sao Jose do Rio Preto, Dept Mol Biol, Immunogenet Lab, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
 FAMERP, Fac Med Sao Jose do Rio Preto, Dept Med 2, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
 HB FUNFARME, Fac Reg Med, Hosp Base, Pediat Endocrinol Outpatient Clin, Sao Jose do Rio Preto - Brazil
 HB FUNFARME, Fundacao Fac Reg Med, Hosp Base, Endocrinol Outpatient Clin, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 4
Web of Science Citations:
Background and ObjectivesThe red blood cell Le(a-b-) phenotype was proposed as risk factor for type 1 diabetes, but contradictory results were published elsewhere. This study re-examined the potential association between Lewis histo-blood group system and type 1 diabetes. Material and MethodsPatients and controls of both sexes, Caucasians and non-Caucasians, matched by sex, geographical origin and ethnicity were evaluated. The red blood cell Lewis phenotypes were identified by gel column agglutination and also inferred from the FUT2 and FUT3 genotyping. ResultsThe Le(a-b-) phenotype was prevalent in patients with type 1 diabetes, and the Le(a-b+) phenotype was prevalent in controls when both were determined by gel columns agglutination. No differences were observed in the frequencies of the Le(a-b-) phenotype inferred from the FUT2 and FUT3 genotyping between patients and controls. ConclusionsThe Lewis red blood cell phenotyping and genotyping reveal divergence in the association of Le(a-b-) phenotype and type 1 diabetes. (AU)