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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lewis histo-blood group system phenotyping and genotyping reveal divergence in the association of Le(a-b-) phenotype and type 1 diabetes

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Author(s):
Previato, M. [1] ; Borim, M. P. [1] ; Liberatore, Jr., R. D. R. [2, 3] ; Pires, A. C. [2, 4] ; Dias, M. A. F. [2, 4] ; Brandao de Mattos, C. C. [1] ; de Mattos, L. C. [1]
Total Authors: 7
Affiliation:
[1] FAMERP, Fac Med Sao Jose do Rio Preto, Dept Mol Biol, Immunogenet Lab, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] FAMERP, Fac Med Sao Jose do Rio Preto, Dept Med 2, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] HB FUNFARME, Fac Reg Med, Hosp Base, Pediat Endocrinol Outpatient Clin, Sao Jose do Rio Preto - Brazil
[4] HB FUNFARME, Fundacao Fac Reg Med, Hosp Base, Endocrinol Outpatient Clin, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Vox Sanguinis; v. 108, n. 3, p. 281-286, APR 2015.
Web of Science Citations: 2
Abstract

Background and ObjectivesThe red blood cell Le(a-b-) phenotype was proposed as risk factor for type 1 diabetes, but contradictory results were published elsewhere. This study re-examined the potential association between Lewis histo-blood group system and type 1 diabetes. Material and MethodsPatients and controls of both sexes, Caucasians and non-Caucasians, matched by sex, geographical origin and ethnicity were evaluated. The red blood cell Lewis phenotypes were identified by gel column agglutination and also inferred from the FUT2 and FUT3 genotyping. ResultsThe Le(a-b-) phenotype was prevalent in patients with type 1 diabetes, and the Le(a-b+) phenotype was prevalent in controls when both were determined by gel columns agglutination. No differences were observed in the frequencies of the Le(a-b-) phenotype inferred from the FUT2 and FUT3 genotyping between patients and controls. ConclusionsThe Lewis red blood cell phenotyping and genotyping reveal divergence in the association of Le(a-b-) phenotype and type 1 diabetes. (AU)

FAPESP's process: 13/10050-5 - Serological, molecular and images in patients with active lesions or acute relapse of ocular infection by Toxoplasma gondii: a study follow-up
Grantee:Mariana Previato
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/17540-2 - Histo blood groups like risk factor for ocular toxoplasmosis
Grantee:Luiz Carlos de Mattos
Support type: Regular Research Grants