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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

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de Oliveira, Raquel [1] ; Moraes, Tamiris Invencioni [1] ; Cerda, Alvaro [1, 2] ; Hirata, Mario Hiroyuki [1] ; Fajardo, Cristina Moreno [1] ; Sousa, Marcela Correia [1] ; Dorea, Egidio Lima [3] ; Silveira Bernik, Myrcia Martins [3] ; Crespo Hirata, Rosario Dominguez [1]
Total Authors: 9
[1] Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ La Frontera, BIOREN CEGIN, Ctr Mol Biol & Pharmacogenet, Temuco - Chile
[3] Univ Sao Paulo, Univ Hosp, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 2

Background: Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. Methods: Anthropometric and body composition parameters were measured in 249 Brazilian subjects (30 to 68 yr). Metabolic and inflammatory markers and adipokines were analyzed in blood samples. ADIPOQ rs2241766 (45 T > G) and IL6 rs1800795 (-174G > C) polymorphisms were analyzed by real-time PCR and PCR-RFLP, respectively. Results: Type 2 diabetes, hypertension, dyslipidemia and increased values of waist circumference, body fat, leptin, fibrinogen, IL-1 beta, hsCRP and TNF alpha were related to obesity (p < 0.05). Multiple linear regression analysis showed a positive correlation between BMI and waist circumference, body fat, leptin, fibrinogen, PAI-1, IL-1 beta, hsCRP and TNF alpha values (p < 0.001) but not with adiponectin. Obese group had altered metabolic status, resistance to leptin and insulin, and atherogenic and pro-inflammatory profiles. ADIPOQ and IL6 variants were not directely related to obesity, leptin resistance or alterations in cardiometabolic markers. Individuals carrying ADIPOQ 45G allele (TG + GG genotype) had higher IL-6, IL-1 beta and TNF alpha levels than TT genotype carriers (p < 0.05). IL6 -174GG genotype was associated with increased IL-1 beta levels (p = 0.033). Conclusion: Obesity is associated with leptin resistance, cardiometabolic alterations and a pro-inflammatory status. Our results are suggestive that ADIPOQ and IL6 polymorphisms contribute to cardiometabolic risk in obese individuals. (AU)

FAPESP's process: 09/10069-2 - Influence of genetic makers on response to a dietary intervention to reduce body weight
Grantee:Rosario Dominguez Crespo Hirata
Support Opportunities: Regular Research Grants