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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular and Biochemical Characterization of CTX-M-131, a Natural Asp240Gly Variant Derived from CTX-M-2, Produced by a Providencia rettgeri Clinical Strain in Sao Paulo, Brazil

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Author(s):
Dropa, Milena [1] ; Ghiglione, Barbara [2] ; Matte, Maria Helena [1] ; Balsalobre, Livia Carminato [1] ; Lincopan, Nilton [3] ; Matte, Glavur Rogerio [1] ; Gutkind, Gabriel [2] ; Power, Pablo [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil
[2] Univ Buenos Aires, Sch Pharm & Biochem, Buenos Aires, DF - Argentina
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Antimicrobial Agents and Chemotherapy; v. 59, n. 3, p. 1815-1817, MAR 2015.
Web of Science Citations: 3
Abstract

CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that bla(CTX-M-131) was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. (AU)

FAPESP's process: 13/07943-8 - Biochemical characterization of new variants of extended-spectrum ²-lactamases (ESBL) identified at São Paulo, SP, Brazil
Grantee:Milena Dropa
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 10/12841-1 - Identification and localization of ²-lactam and tetracycline resistance genes, in clinical and environmental Enterobacteriaceae and Aeromonas hydrophila strains
Grantee:Maria Helena Matte
Support Opportunities: Regular Research Grants
FAPESP's process: 08/08312-3 - Molecular identification of ESBL-encoding resistance genes, detected in Enterobacteriaceae clinical strains related to hospital infections
Grantee:Maria Helena Matte
Support Opportunities: Regular Research Grants