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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Selective Hydrogenation of Indolizines: An Expeditious Approach To Derive Tetrahydroindolizines and Indolizidines from Morita-Baylis-Hillman Adducts

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Teodoro, Bruno V. M. [1] ; Correia, Jose Tiago M. [1] ; Coelho, Fernando [1]
Total Authors: 3
[1] Univ Estadual Campinas, Inst Chem, Lab Synth Nat Prod & Drugs, BR-13083970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Organic Chemistry; v. 80, n. 5, p. 2529-2538, MAR 6 2015.
Web of Science Citations: 26

In this study, we describe the hydrogenation of indolizines derived from Morita-Baylis-Hillman adducts. We demonstrate that functionalized tetrahydroindolizines and indolizidines can be prepared selectively, at low pressure, by simply adjusting the acidity of the medium. Using this simple and straightforward strategy, substituted tetrahydroindolizines and indolizidines were obtained diastereoselectively in high yield. (AU)

FAPESP's process: 12/21809-0 - Organocatalysed synthesis of indolizidinic and quinolizidinic N-heterocycles from Morita-Baylis-Hillman adducts
Grantee:José Tiago Menezes Correia
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC