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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heart Rate Detrended Fluctuation Indexes as Estimate of Obstructive Sleep Apnea Severity

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Pereira da Silva, Eduardo Luiz [1, 2] ; Pereira, Rafael [3] ; Reis, Luciano Neves [4] ; Pereira, Jr., Valter Luis [1] ; Campos, Luciana Aparecida [1] ; Wessel, Niels [5] ; Baltatu, Ovidiu Constantin [1]
Total Authors: 7
[1] Camilo Castelo Branco Univ UNICASTELO, CITE, BR-12247016 Sao Jose Dos Campos, SP - Brazil
[2] Univ Iguacu Campus V, Rio De Janeiro - Brazil
[3] State Univ Southwest Bahia UESB, Dept Biol Sci, Jequie, BA - Brazil
[4] Sleep Inst Itaperuna, Rio De Janeiro - Brazil
[5] Humboldt Univ, D-10099 Berlin - Germany
Total Affiliations: 5
Document type: Journal article
Source: MEDICINE; v. 94, n. 4 JAN 2015.
Web of Science Citations: 5

In the present study, we aimed at investigating a heart rate variability (HRV) biomarker that could be associated with the severity of the apnea-hypopnea index (AHI), which could be used for an early diagnosis of obstructive sleep apnea (OSA). This was a cross-sectional observational study on 47 patients (age 36 + 9.2 standard deviation) diagnosed with mild (23.4%), moderate (34%), or severe (42.6%) OSA. HRV was studied by linear measures of fast Fourier transform, nonlinear Poincare analysis, and detrended fluctuation analysis (DFA)-DFA alpha 1 characterizes short-term fluctuations, DFA alpha 2 characterizes long-term fluctuations. Associations between polysomnography indexes (AHI, arousal index {[}AI], and oxygen desaturation index {[}ODI]) and HRV indexes were studied. Patients with different grades of AHI had similar sympathovagal balance levels as indicated by the frequency-domain and Poincare HRV indexes. The DFA alpha 2 index was significantly positive correlated with AHI, AI, and ODI (Pearson r: 0.55, 0.59, and 0.59, respectively, with P < 0.0001). The ROC analysis revealed that DFA alpha 2 index predicted moderate and severe OSA with a sensitivity/specificity/area under the curve of 0.86/0.64/0.8 (P = 0.005) and 0.6/0.89/0.76 (P = 0.003), respectively. Our data indicate that the DFA alpha 2 index may be used as a reliable index for the detection of OSA severity. (AU)

FAPESP's process: 13/06698-0 - Mathematical biomarkers for autonomic regulation of cardiovascular system
Grantee:Luciana Aparecida Campos Baltatu
Support type: Regular Research Grants
FAPESP's process: 13/14724-0 - Functional biomarkers for the extracranial vascular disease
Grantee:Ovidiu Constantin Baltatu
Support type: Regular Research Grants