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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cerebellar vermis H-2 receptors mediate fear memory consolidation in mice

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Gianlorenco, A. C. L. [1] ; Riboldi, A. M. [1] ; Silva-Marques, B. [1] ; Mattioli, R. [1]
Total Authors: 4
[1] Univ Fed Sao Carlos, Physiotherapy Dept, Ctr Biol Sci & Hlth, Neurosci Lab, BR-13565905 Sao Carlos - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Neuroscience Letters; v. 587, p. 57-61, FEB 5 2015.
Web of Science Citations: 6

Histaminergic fibers are present in the molecular and granular layers of the cerebellum and have a high density in the vermis and flocullus. Evidence supports that the cerebellar histaminergic system is involved in memory consolidation. Our recent study showed that histamine injections facilitate the retention of an inhibitory avoidance task, which was abolished by pretreatment with an H-2 receptor antagonist. In the present study, we investigated the effects of intracerebellar post training injections of H-1 and H-2 receptor antagonists as well as the selective H-2 receptor agonist on fear memory consolidation. The cerebellar vermi of male mice were implanted with guide cannulae, and after three days of recovery, the inhibitory avoidance test was performed. Immediately after a training session, animals received a microinjection of the following histaminergic drugs: experiment 1, saline or chlorpheniramine (0.016, 0.052 or 0.16 nmol); experiment 2, saline or ranitidine (0.57, 2.85 or 5.07 nmol); and experiment 3, saline or dimaprit (1,2 or 4 nmol). Twenty-four hours later, a retention test was performed. The data were analyzed using one-way analysis of variance (ANOVA) and Duncan's tests. Animals microinjected with chlorpheniramine did not show any behavioral effects at the doses that we used. Intra-cerebellar injection of the H-2 receptor antagonist ranitidine inhibited, while the selective H-2 receptor agonist dimaprit facilitated, memory consolidation, suggesting that H-2 receptors mediate memory consolidation in the inhibitory avoidance task in mice. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/15836-1 - Influence of cerebellar histaminergic neural system on emotional memory in mice
Grantee:Anna Carolyna Lepesteur Gianlorenço
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/17496-3 - Influence of the cerebellar histaminergic system on emotional memory in mice
Grantee:Rosana Mattioli
Support type: Regular Research Grants