Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neonatal Sepsis and Inflammatory Mediators

Full text
Machado, Juliana Reis [1, 2] ; Soave, Danilo Figueiredo [3] ; da Silva, Marcos Vinicius [4] ; de Menezes, Liliana Borges [1] ; Etchebehere, Renata Margarida [5] ; Goncalves dos Reis Monteiro, Maria Luiza [2] ; dos Reis, Marlene Antonia [2] ; Miranda Correa, Rosana Rosa [2] ; Nunes Celes, Mara Rubia [1, 3]
Total Authors: 9
[1] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Dept Pathol, BR-74605050 Goiania, Go - Brazil
[2] Univ Fed Goias, Inst Biol & Nat Sci, Dept Gen Pathol, BR-74605050 Uberaba, MG - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Fed Triangulo Mineiro, Inst Biol & Nat Sci, Immunol Lab, BR-38025180 Uberaba, MG - Brazil
[5] Univ Fed Triangulo Mineiro, Clin Hosp, Surg Pathol Serv, BR-38025180 Uberaba, MG - Brazil
Total Affiliations: 5
Document type: Review article
Source: Mediators of Inflammation; 2014.
Web of Science Citations: 37

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion. (AU)

FAPESP's process: 11/08234-5 - Experimental septic cardiomyopathy mimicking the common clinical scenario (two-hit model): cecal ligation and puncture followed by Pseudomonas aeruginosa-induced pneumonia
Grantee:Maria José Figueiredo
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/18427-5 - Influence of hypoxia on CD44/CD24 adhesion molecules expression in biopsies and cell lines of benign and malignant salivary gland neoplasm.
Grantee:Danilo Figueiredo Soave
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/23220-0 - Role of the phosphoinositide-3-kinase/serin-treonin kinase (PI3K/AKT) signaling pathway in the expression of dystrophin in the myocardium of animals submitted to cecal ligation and puncture (CLP).
Grantee:Erica Carolina Campos Pulici
Support type: Scholarships in Brazil - Post-Doctorate