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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors

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Oliveira, Denise Tostes [1] ; de Santis, Lais Priscila [1] ; Assao, Agnes [1] ; Tjioe, Kellen Cristine [1] ; Nonogaki, Suely [2] ; Pereira Lauris, Jose Roberto [3] ; Soares, Fernando Augusto [4]
Total Authors: 7
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil
[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Bauru, SP - Brazil
[4] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BMC ORAL HEALTH; v. 14, DEC 5 2014.
Web of Science Citations: 5

Background: The aims of this study were to investigate the immunolocalization of ezrin and its relationship with the podoplanin expression in keratocystic odontogenic tumors. Material and Methods: The immunohistochemical expressions of ezrin and podoplanin by odontogenic epithelium were evaluated in keratocystic odontogenic tumors using monoclonal antibodies. Results: Our results showed strong cytoplasmic ezrin and membranous podoplanin expressions in basal epithelial layer of all keratocystic odontogenic tumors. The cytoplasmic and membranous ezrin expressions were also detected in suprabasal epithelial layers of tumors. Statistically significant difference between cellular immunolocalization of ezrin and podoplanin odontogenic epithelium were found by Wilcoxon's test (p < 0.05). No correlation between both proteins in keratocystic odontogenic tumors was detected by Spearman test. Conclusions: These results suggest that ezrin and podoplanin may contribute to the expansive growth and local invasiveness of keratocystic odontogenic tumors. Additionally, as both proteins were overexpressed by odontogenic epithelium, their possible roles need to be further explored in benign odontogenic tumors. (AU)

FAPESP's process: 12/13411-6 - The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 13/16999-7 - Correlation of podoplanin, ezrin and Rho-A expression in oral squamous cell carcinoma
Grantee:Agnes Assao
Support Opportunities: Scholarships in Brazil - Master