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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

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de Meneses Fujii, Tatiane Mieko [1] ; Jacob, Patricia Silva [1] ; Yamada, Monica [1] ; Borges, Maria Carolina [1] ; Norde, Marina Maintinguer [1] ; Pantaleao, Lucas Carminatti [2] ; de Oliveira, Daniela Moura [1] ; Tirapegui, Julio [3] ; de Castro, Inar Alves [3] ; Borelli, Primavera [4] ; Fock, Ricardo Ambrosio [4] ; Rogero, Marcelo Macedo [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol, BR-01246904 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-01246904 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Analyzes, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION; v. 65, n. 8, p. 967-976, DEC 2014.
Web of Science Citations: 2
Abstract

To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p<0.05) and total blood cholesterol (p<0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of kappa B (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-kappa B phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD. (AU)

FAPESP's process: 09/12790-0 - Effect of Ilex paraguariensis ingestion on proteins expression related to the insulin signalling in the liver of rats submitted to high fat diet
Grantee:Patrícia Silva Jacob
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/14164-7 - Effect of yerba mate (Ilex paraguariensis) aqueous extract on the expression of proteins involved in inflammatory response of the white adipose tissue from rats fed with a high fat diet
Grantee:Monica Yamada
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/14609-9 - Effect of yerba-mate (Ilex paraguariensis) aqueous extract on the expression of proteins involved in the regulation of insulin signaling pathway on soleous muscle from rats fed with a high-fat diet
Grantee:Tatiane Mieko de Meneses Fujii
Support type: Scholarships in Brazil - Master