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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Counter-regulatory effects played by the ACE - Ang II-AT1 and ACE2-Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function:perspectives to pharmacological approaches in controlling vascular complications

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Pernomian, Laena [1] ; Pernomian, Larissa [2] ; Araujo Restini, Carolina Baraldi [3]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-05508 Sao Paulo - Brazil
[3] Univ Ribeirao Preto, Dept Med, BR-14096900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Vasa-European Journal of Vascular Medicine; v. 43, n. 6, p. 404-414, NOV 2014.
Web of Science Citations: 16

The Renin-Angiotensin system plays an important role in the regulation of systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two described axes, the ACE - Ang II - AT1 receptor, with Ang II as the main mediator, and the ACE2 - Ang-(1 - 7) - Mas receptor, with Ang-(1 - 7) responsible for the main effects. The main vascular effect induced by Ang II is contraction, while Ang-(1 - 7) includes relaxation in several vascular beds. Ang II also activates several cytokines that are important in the genesis of vascular inflammation and hypertrophy. In this context, Ang-(1 - 7) seems to have a protective role. Both AT, and Mas receptors modulate, in different ways, the generation of, which are involved in the control of vascular tone and the genesis of vascular dysfunction triggered by several diseases, including diabetes mellitus, arterial hypertension and atherosclerosis. Thereby, this review presents an overview of the modulation played by the whole Renin-Angiotensin system on the reactive oxygen species-mediated control of vascular tone and the oxidative stress-elicited vascular dysfunction. (AU)

FAPESP's process: 12/00640-7 - Study of the consequences of the inflammatory process induced by AT1 receptors during atherosclerosis on the ACE2 - angiotensin-(1-7) - Mas axis in mouse aorta and the involvement of Mas receptors in the vaso- and atheroprotective effects of losartan
Grantee:Larissa Pernomian
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 10/02754-4 - Effects of the C-type natriuretic peptide in the calcium intracellular signaling on isolated aorta endothelial cells from normotensive and renal hypertensive rats
Grantee:Laena Pernomian
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/11205-7 - Modulation played by C-type natriuretic peptide (CNP) on the contractile response induced by phenylephrine on thoracic aorta and mesenteric resistance arteries isolated from rats submitted to septic shock
Grantee:Laena Pernomian
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/09019-3 - Consequences of dyslipidemia on the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - mas axes from the angiotensinergic system in aorta from young and adult LDLr knockout mice
Grantee:Ana Maria de Oliveira
Support type: Regular Research Grants