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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Compatibility of Cassava Starch Films as Nitric Oxide Carrier for Potential Medical Device

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Aguiar, Helena de Fazio [1] ; Roveda Junior, Antonio Carlos [2] ; Piva, Renan de Jesus [1] ; Onoda, Kevin Akira [1] ; Miyakawa, Ayumi Aurea [3] ; Krieger, Jose Eduardo [3, 4] ; Franco, Douglas Wagner [2] ; Tadini, Carmen Cecilia [1]
Total Authors: 8
[1] Univ Sao Paulo, Dept Chem Engn, BR-05508010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403900 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Cardiopneumol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 132, n. 2 JAN 10 2015.
Web of Science Citations: 3

Films prepared with bioabsorbable materials (cassava starch, glycerol, and carboxymethyl cellulose (CMC)) can be used as an external support in the myocardial revascularization surgery, releasing nitric oxide (NO) during the tissue regeneration. In the present study, these materials submitted to in vitro degradation tests under physiological conditions, presented the reduction of 38% of weight loss by the modification of native starch using sodium trimetaphosphate (STMP) (15 g/100g of starch). The CMC addition of 10 g/100g of cassava starch increased 119% of the tensile strength of the films in comparison with films prepared without CMC. It was verified that the ruthenium complex trans-{[}Ru(NH3)(4)(isn)(NO)](BF4)(3) incorporated in the starch based films behave similarly as in aqueous solution, releasing NO by photochemical reaction. Macrophage cells were detected in in vivo degradation tests in rats around the implant after 1 and 7 days, and complete biodegradation was observed after 30 days. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41382. (AU)

FAPESP's process: 12/23651-4 - Nitrosyl and nitroxyl as ligands on Ru(II): synthesis, kinetics, reactivity and thermodynamics
Grantee:Douglas Wagner Franco
Support Opportunities: Regular Research Grants
FAPESP's process: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther
Grantee:José Eduardo Krieger
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/16057-3 - Study of biodegration of films based on cassava starch for potential medical application
Grantee:Renan de Jesus Piva
Support Opportunities: Scholarships in Brazil - Scientific Initiation