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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film

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Roveda, Jr., Antonio Carlos [1] ; Aguiar, Helena de Fazio [2] ; Miranda, Katrina M. [3] ; Tadini, Carmen Cecilia [2] ; Franco, Douglas Wagner [1]
Total Authors: 5
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Escola Politecn, Dept Chem Engn, BR-05508010 Sao Paulo - Brazil
[3] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 - USA
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 2, n. 41, p. 7232-7242, 2014.
Web of Science Citations: 7

A new nitric oxide-releasing material produced with cassava starch is described. The ruthenium nitrosyl complex trans-{[}Ru(NH3)(4)(isn)NO](BF4)(3) (RuNOisn; isn = isonicotinamide) is able to release NO upon either photolysis or chemical reduction. Impregnating this complex under mild conditions into cassava starch (CS) films produced a NO-delivery platform (CSx-RuNOisn). Spectroscopic analysis of CSx-RuNOisn indicates that the coordination sphere of RuNOisn remains intact during film production. Exposure of CSx-RuNOisn to long wave UV-light (lambda(irr) = 355 nm) leads to NO release and formation of the paramagnetic photoproduct trans-{[}RuIII(NH3)(4)isn(H2O)](3+) in the CS film. Reaction of this aquaruthenium(III) complex with aqueous nitrite regenerates RuNOisn in the film. Delivery of NO upon photolysis of CSx-RuNOisn was verified by trapping with oxymyoglobin. Moreover, NO release upon chemical reduction was carried out using L-cysteine as a reductant. Cysteine-mediated NO delivery from CSx-RuNOisn persisted for more than 7 h, during which physiologically relevant NO concentrations were liberated. These results suggest that CSx-RuNOisn is a promising candidate for use in biological applications. (AU)

FAPESP's process: 12/23651-4 - Nitrosyl and nitroxyl as ligands on Ru(II): synthesis, kinetics, reactivity and thermodynamics
Grantee:Douglas Wagner Franco
Support Opportunities: Regular Research Grants