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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An easy access to halogenated and non-halogenated spiro-hexadienones

Full text
Author(s):
Martins, Lucimara J. [1] ; Ferreira, Bruno R. V. [1] ; Almeida, Wanda P. [1] ; Lancellotti, Marcelo [2] ; Coelho, Fernando [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Tetrahedron Letters; v. 55, n. 38, p. 5264-5267, SEP 17 2014.
Web of Science Citations: 6
Abstract

We describe an improved protocol for the synthesis of spiro-hexadienones from Morita-Baylis-Hillman adducts. Solvent modification and temperature resulted in a significant increase in the yield. This protocol was used to synthesize mono- and dibrominated spiro-hexadienones in good overall yields. This report is the first to describe the synthesis of halogenated spiro-hexadienones from Morita-Baylis-Hillman adducts. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action
Grantee:Ronaldo Aloise Pilli
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 09/18390-4 - Morita-Baylis-Hillma in synthesis: structural diversity and biological evaluation of spirocyclohexadienones
Grantee:Lucimara Júlio Martins
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/20033-5 - Synthesis of heterocycles using Morita-Baylis-Hillman adducts
Grantee:Fernando Antonio Santos Coelho
Support Opportunities: Regular Research Grants