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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes

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Kurokawa, Cilmery Suemi [1] ; Hashimoto, Miriam [1] ; Suppo de Souza Rugolo, Ligia Maria [1] ; Bentlin, Maria Regina [1] ; Golin, Marjorie de Assis [2] ; Peracoli, Jose Carlos [3] ; da Silva, Marcia Guimaraes [4] ; Corrente, Jose Eduardo [5] ; Wiegerinck Fekete, Saskia Maria [1]
Total Authors: 9
[1] Univ Estadual Paulista, Dept Pediat, Sao Paulo - Brazil
[2] Univ Estadual Paulista, Ctr Blood, Sao Paulo - Brazil
[3] Univ Estadual Paulista, Dept Gynaecol & Obstet, Sao Paulo - Brazil
[4] Univ Estadual Paulista, Dept Pathol, Botucatu Med Sch, Sao Paulo - Brazil
[5] Univ Estadual Paulista, Biostat Dept, Biosci Inst Botucatu, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: TURKISH JOURNAL OF PEDIATRICS; v. 55, n. 6, p. 598-605, NOV-DEC 2013.
Web of Science Citations: 2

This study aimed to evaluate the levels of pro-and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM. (AU)

FAPESP's process: 10/11507-0 - Cell symposia: inflammation and disease
Grantee:Cilmery Suemi Kurokawa
Support Opportunities: Research Grants - Meeting - Abroad