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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

First detection of Leishmania infantum DNA within the brain of naturally infected dogs

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Grano, Fernanda G. [1] ; Melo, Guilherme D. [1] ; Belinchon-Lorenzo, Silvia [2] ; Gomez-Nieto, Luis C. [2] ; Machado, Gisele F. [1]
Total Authors: 5
[1] Univ Estadual Paulista, UNESP, Coll Vet Med, Lab Appl Pathol LApap, Aracatuba, SP - Brazil
[2] Univ Extremadura, Fac Vet, Parasitol Unit, LeishmanCeres Lab GLP Compliance Certified, Caceres - Spain
Total Affiliations: 2
Document type: Journal article
Source: Veterinary Parasitology; v. 204, n. 3-4, p. 376-380, AUG 29 2014.
Web of Science Citations: 7

Visceral leishmaniasis is an anthropozoonosis caused by the protozoan Leishmania infantum (L. chagasi). In dogs, the disease presents with systemic manifestations, including neurological disorders. There are rare reports of the presence of the parasite in the central nervous system of infected dogs, and some evidences of inflammatory lesions and the breakdown of cerebral barriers have been described. The aim of this study was to investigate the presence of L infantum DNA in five specific areas of the brains of 20 naturally infected dogs by real-time PCR. For the first time, the presence of parasite DNA was detected and quantified in the brains of naturally infected dogs, in all evaluated regions. These data provide strong evidence of the presence of the Leishmania parasite in the nervous milieu and contribute to a new perspective of the pathogenesis of visceral leishmaniasis. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/03504-4 - Evaluation of T lymphocyte subsets in blood and cerebrospinal fluid in dogs with visceral leishmaniasis: correlation with brain lesions
Grantee:Fernanda Grecco Grano
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/10415-0 - Neuropathogenesis of canine visceral leishmaniasis: investigation of inflammatory mediators
Grantee:Guilherme Dias de Melo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/21129-9 - Real-Time PCR analysis in the brain of naturally infected dogs by Leishmania chagasi
Grantee:Fernanda Grecco Grano
Support Opportunities: Scholarships abroad - Research Internship - Master's degree