Graduated in Medicine from the Federal University of Ceará (1991), Master of Sciences in Medicine (Nephrology) from the Federal University of São Paulo (1997), specialization in Transplantation Immunology at the University of Tours (Diplome des Etudes Appronfodies, France, 1997-1999), PhD in Medicine (Nephrology) by the Federal University of São Paulo (2000), postdoc at Imperial College London (2000-2003) and habilitation (Livre Docencia) at the Federal University of São Paulo (Medicine) in 2006. He is currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). He was Visiting Professor at the University of Tours, France in 2006. The laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity and allo. Full member of São Paulo Research Academy.Full member of Brazilian Academy of Sciences. CNPq 1A grantee award. Deputy Provost at the USP Graduate Office (2022-2023). (Source: Lattes Curriculum)
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Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
The ICB-USP has flow cytometry Facilities that serve more than 100 users and operate for more than 40 hours/week. This technology has been evolving very quickly. With the advent of spectral cytometry, the expectation of the scientific community is that a cytometer is capable of monitoring at least 20 markers simultaneously. This is not a reality for the conventional (non-spectral) cytomet…
(Only some records are available in English at this moment)
Chronic kidney diseases (CKD), mainly Glomerulopathies (GPs), are major health issues worldwide. GPs are difficult to manage due to variable responses to treatment and chances of reappearance after transplantation. Podocytes are the central cell in numerous GPs and CKD, playing crucial roles in maintaining renal physiology. We hypothesize that podocytes are renal-sensing cells that connec…
(Only some records are available in English at this moment)
The chemotherapeutic agent cisplatin has been used against solid tumors for decades, but it also causes a high incidence of acute and chronic nephrotoxicity. Cisplatin-induced renal dysfunction seems to occur due to both direct DNA damage and depletion of antioxidants in renal cells, particularly from proximal tubule. The initial injury in this segment after cisplatin treatment induce a p…
Chronic kidney disease (CKD) is a global public health problem and involves significant metabolic changes, which are important for the clinical evolution of the disease. Hypoxia and changes in the HIF-1 alfa pathway participate in the development and progression of different CKD models. Thus, understanding the metabolic parameters altered in CKD is of great importance for understanding th…
Type 2 diabetes mellitus (type 2 DM) is a metabolic condition resulting from insulin resistance (IR) that, in 2021, affected approximately 537 million people between 20 and 79 years. Diabetes is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), commonly known as diabetic kidney disease (DKD). DKD affects approximately 40% of people with type 2 DM in the U…
(Only some records are available in English at this moment)
Acute kidney injury (AKI) is defined by a sudden loss of renal excretory function lasting up to seven days, which can be determined based on the assessment of serum creatinine levels and oliguria. ARF is considered a global public health problem, affecting approximately 20% of hospitalized patients and is associated with 50% of mortality rates in patients admitted to intensive care units …
DNA undergoes daily damage from environmental, chemical, physical, and biological agents. These damages can be detected and repaired through specific repair pathways depending on the type of damage. One of the most important repair pathways involved in genetic maintenance is the nucleotide excision repair pathway, in which the XPC protein plays a role in lesion recognition and DNA strand …
(Only some records are available in English at this moment)
The gut microbiota has several immunoregulatory mechanisms that induce the host's immune tolerance against the microbiome throughout life. These organisms use fibers from the diet as nutrients for their metabolic fermentation, generating different types of shortchain fatty acids (SCFAs) as metabolic by-products. Among them, butyrate has been shown to induce Tregs, and its oral administrat…
The circadian rhythms are a cell-autonomous process that regulates the daily cycles of living species. In vertebrates, the circadian rhythms are controlled by an internal clock in a transcription-translation loop where the master genes clock and bmal induce the transcription of clock target genes, including its own repressors PER and CRY. Emerging studies have shown a relationship between…
Dietary restriction and exercise are known to promote numerous physiological benefits. These include extending longevity, improving metabolic profiles and tissue regeneration, as well as reducing neurodegeneration, bone loss, cardiovascular disease, and the incidence of cancer. Emerging evidence indicates that these interventions can also optimize immune responses. This can be mediated di…
(Only some records are available in English at this moment)
| 6 / 6 | Ongoing research grants |
| 24 / 18 | Completed research grants |
| 20 / 20 | Ongoing scholarships in Brazil |
| 101 / 85 | Completed scholarships in Brazil |
| 35 / 35 | Completed scholarships abroad |
| 186 / 164 | All research grants and scholarships |
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CV Lattes
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