Associate Professor at the Department of Pharmacology, ICB, USP. Holds a Ph.D. in Science (Pharmacology) from the University of São Paulo (2005) with Ph.D. Internships at Complutense University of Madrid, Spain (2002) and Stanford University, Palo Alto, CA-USA. Graduated in Pharmacy-Biochemistry from the São Paulo State University (UNESP - 1999) and was a post-doc fellow at the Department of Pharmacology ICB/USP (2006) and at Stanford University (2006-2009). My scientific focus is in Pharmacology, with the emphasis in Neurosciences, Neuroendocrinology, Neuroinflammation, and Biochemical and Molecular Pharmacology. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
With the demonstration of the protective and antioxidant effects of estrogen (E2), the female sex hormone, in several pathologies, including the central nervous system (CNS), it has become mandatory to better comprehend its actions in the body, including in males. Clinical and experimental studies show such actions of E2 in stroke, the second leading cause of death and disability worldwid…
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer's, Multiple Sclerosis and Parkinson's Disease. On the other side, the spread o…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies focusing on stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating stress-related disorder. The amygdala is a fundamental brain structure essential for beh…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies devoted to stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating anxiety-related disorder. The amygdala is a key brain structure essential for behavioral …
Multiple sclerosis (MS) is a debilitating neurological and autoimmune disease, characterized by inflammation, demielinization, and neurodegeneration. Neuroinflammation is an important finding in MS pathogenesis, contributing for the progression of the disease. Glial cells (microglia and astrocytes) also have a key role in the progression of MS. Systemic corticosteroids, such as dexamethas…
Prolonged periods of stress may cause or potentiate pathologies. Stress activates the hypothalamic-pituitary-adrenal axis (HPA axis), ultimately releasing glucocorticoid hormones (GCs) which activate mineralocorticoid (MR) and glucocorticoid (GR) receptors. These receptors will mediate rapid and delayed responses to stress and the formation and maintenance of aversive memories. MR and GR …
Stress is a fundamental condition for survival. It concerns the ability to respond physiologically and behaviorally to events that threaten the physical and emotional integrity of the organism. Added to stress, anxiety and the ability to store information as memories constitute a basic set of abilities of several animal species, including humans. Individuals deal with aversive situations …
Cardiovascular diseases are the leading cause of death in the world and include cerebrovascular diseases such as cerebrovascular accident (CVA). Most of the risk factors for stroke are modifiable, but non-modifiable factors, such as the individual's sex and age, interfere with their predisposition to suffer the accident. Epidemiological studies suggest that estrogen (mainly 17²-estradiol)…
(Only some records are available in English at this moment)
Aging is a physiological process that occurs in all living organisms. Associated with an increase of life expectancy and habits, such as poor diet and a sedentary life, there is an increase in the probability of appearance of neurodegenerative diseases, potentially related to these conditions. The Klotho protein is intrinsically related to the senescence process, in addition to acting in …
(Only some records are available in English at this moment)
The bidirectional communication between the gastrointestinal tract (GI) and the brain has gained attention as a therapeutic target for psychiatric disorders, such as depression, anxiety, and stress-related disorders. The vagus nerve is a critical component of the autonomic nervous system implicated in the gut-to-brain communication. Subcutaneously vagal stimulation has been increasingly u…
The exposure to environmental factors during the perinatal period of development is associated with long-term changes in the organism. Exposure to stress and glucocorticoids (GCs) during this period can lead to several pathologies and systems malfunction. To accelerate lung maturation and reduce neonatal respiratory distress syndrome (RDS), synthetic GC receptor (GR) agonists (sGCs), as d…
Asthma, a chronic inflammatory disease affecting the airways, represents a major cost for public healthcare systems worldwide. Diverse lines of evidence, including data from our group, shows that the airway neuronal network in asthma is changed and contributes to airway hyperresponsiveness and inflammation This plasticity might, therefore, represent a potential druggable target.For a long…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 20 / 13 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 37 / 29 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID