Graduation at School of Pharmaceutical Sciences of Ribeirão Preto/Universidade de São Paulo, Master in Applied Immunology/School of Medicine of Ribeirão Preto/Universidade de São Paulo, and Doctorate in Clinical Medicine/School of Medicine of Ribeirão Preto/Universidade de São Paulo. Im a Scientific and Technological Researcher at the Blood Center of Ribeirão Preto/Cell Therapy Center (CTC)/National Institute of Stem Cells and Cell Therapy (INCTC). Principal Investigator at the Center for Viral Surveillance and Serological Assessment (CeViVas). Experience in Virology, Immunology, Genetics, and Molecular Biology, with an emphasis on infectious diseases with an impact on cell therapy and molecular characterization of emerging viruses. Basic research related to the biology of mesenchymal and pluripotent stromal stem cells. Studies to understand the cellular components of the hematopoietic niche in sickle cell disease. Technical Manager of the Laboratory of Advanced Molecular Biology at the Blood Center of Ribeirão Preto. Experience in Quality Control for molecular testing and developing molecular platforms to release advanced cellular products. Member of the Executive Secretariat - Animal/Human Sector of the Comissão Técnica Nacional de Biossegurança/CTNBio (Ministry of Science and Technology). (Source: Lattes Curriculum)
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The bone marrow microenvironment and its cellular and molecular complexity in sickle cell anemia (SCA) are still poorly understood. SCA is a genetic disease characterized by the synthesis of an altered hemoglobin, HbS. Under hypoxia, HbS polymerizes and results in hemolysis and episodes of vaso-occlusion, leading to important clinical complications, with evident inflammation. The conseque…
Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
With the rapid dissemination of Zika virus (ZIKV) in the Tropical world and its entry in Brazil, a rapid strategy with interaction of different scientific areas is necessary in order to understand better the infection pathogenesis. A significant number of studies performed in Brazil are destined towards understanding ZIKV biology; nevertheless, specific efforts are necessary for the devel…
The transmission of infectious diseases by the transfusion of contaminated blood components has constantly decreased due to great advancements in molecular methods for diagnostic investigation. The Nucleic Acid Technologies (NAT) for the hepatitis C virus (HCV) and for the human immunodeficiency virus (HIV) has been recommended by the Brazilian law since 2002 (Ordinance n° 262/2002 of Min…
Dengue is an arboviral fever caused by four distinct Dengue virus (DENV) serotypes, transmitted by the bite of Aedes mosquitoes. About 390 million infections occur annually in tropical and subtropical countries. Brazil has the highest number of DENV infections among Latin American countries. The northwest of the State of São Paulo is considered an endemic area for the infection. In this r…
Sickle cell anemia (SCA) is a disease in which a point mutation in the beta-globin chain (HbB) gene, type A - T, leads to the synthesis of "S" globins and formation of hemoglobins (HbS) that polymerize within the red blood cells, changing their biconcave structure making them sickle. These cells present greater dehydration and endothelial adhesion, in addition to a high degree of hemolysi…
The hematopoietic niche is a highly dynamic, orchestrated and heterogeneous microenvironment for the cell types that make up. This microenvironment acts on the regulation of the hematopoietic system, which is the controller of the production of all the blood cells of the organism in homeostasis or stress. Among the cell types that make up the niche, there are Multipotent Mesenchymal Strom…
Red blood cell alloimmunization in sickle cell disease (SCD) affects more than 30% of individuals in transfusion therapy. It is the main complication related to blood transfusion in SCD and may be related to the antigenic disparity between donors and patients or with a deficiency in the control of the cellular immune response. The prophylaxis adopted to prevent alloimmunization is to supp…
It has been estimated that worldwide more than 20 million people are infected by HTLV-1. In Brazil, there are approximately 2.5 million carriers of this virus, which places the country on the first position regarding the absolute number of infected individuals. HTLV-1 is associated with two main clinical diseases: i) adult T-cell (ATLL) leukemia / lymphoma; and ii) progressive myelopathy …
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Human T cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be discovered. Approximately, 10 - 20 million people are infected with HTLV-1 worldwide, and in Brazil, there are about 2.5 million HTLV-1-carriers. The main HTLV-1-associated diseases are the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and the adult T cell leukemia/lymphoma (ATL). Cu…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 14 | All research grants and scholarships |
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CV Lattes
ORCID