Abstract
Sickle cell disease is the most common monogenic disorder and severe throughout the world. It is characterized by acute illness and progressive organ damage. Results from a single mutation at position 6 of ² chain, with glutamate in hemoglobin to valine in hemoglobin S. Aiming to treat the symptoms of this disease, the phtalimide derivative LAPDESF-SCD03 was planned to have nitric oxide d…