Abstract
The purpose of the FACSymphony A5 SE Flow Cytometer is to analyze (phenotipar) distinct cellular populations of samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumours, solid organs or other fabrics. (AU)
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João Santana da Silva
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade de São Paulo (1976), master's at Biochemistry from Universidade de São Paulo (1979) and doctorate at Biochemistry from Universidade de São Paulo (1983). He is currently full professor at Faculdade de Medicina de Ribeirão Preto. Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: trypanosoma cruzi, citocinas, chemokines, quimiocinas and t. cruzi. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Standing alone |
| Para caminar por sus propios medios |
| News published in Agência FAPESP Newsletter about the researcher |
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Research grants
- EMU granted in process 2016/23618-8: FACSymphony A5 SE Flow Cytometer, AP.EMU
- EMU granted in case 2016/23618-8: Cell Sorter Aria III CDU 5B/3R/6V, AP.EMU
Abstract
The purpose of the Cell Sorter Aria III CDU 5B/3R/6V is to analyze and separate distinct cell populations from samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumors, solid organs, or other tissues. The equipment will be part of the equipment park of the Translational Medicine Research Platform - Fiocruz/Ribeirão Preto School of Medicine - USP, and will b…
- SPIICA - the São Paulo-Imperial College (UK) Immune Correlates in Arbovirus Infection Network: special emphasis on CHIKV, AP.TEM
Abstract
Emerging and re-emerging diseases are a major public health problem. In the past years, the world has been threatened by several important emerging or re-emerging infectious diseases, such as Ebola, Avian Influenza A, Yellow Fever (YFV), Dengue (DENV), West Nile Fever (WNV) among others. In Brazil, the emerging infections caused by arboviruses such as DENV and YIF are historical and have …
(Only some records are available in English at this moment)
- Further studies: CD4 T cell immune correlates of Zika virus exposure, AP.R SPRINT
Abstract
Current knowledge of T cell immunity to Zika virus is minimal. For a disease of such diverse outcomes, from asymptomatic exposure to Guilain-Barre syndrome or neonatal microcephaly, there is a pressing need to characterize immunity so as to comprehend the difference between protective and pathogenic T cell responses. In West Nile virus (WNV) infection, for example, neuropathgenic complica…
- CD4 T cell immune correlates of Zika virus exposure, AP.R
Abstract
A feature common to the pathogenesis of flavivirus exposure in humans is the diversity of clinical outcomes. In the case of exposure to Zika virus, outcomes can range from asymptomatic exposure to fever, rash, joint pain, conjunctivitis, Guillain Barre syndrome and probably, neonatal microcephaly. Some regions of Brazil (including Sao Paulo where our study will be based) have witnessed a …
- Interplay of the immune response in the obesity and tuberculosis, AP.R
Abstract
Among bacterial infections, tuberculosis is the disease which causes the highest number of deaths. Even being extensively studied considering the relationship of the host with the pathogen Mycobacterium tuberculosis, etiologic agent of this disease, the factors that contribute for the development of active and progressive tuberculosis in immune competent individuals are complex and still …
(Only some records are available in English at this moment)
Scholarships in Brazil
- Generation and genotyping of transgenic animals (Cre-lox System) for experimental models, BP.TT
- Regulation of pathogenic gravity by interleukin IL-27 triggered in experimental infection by Plasmodium chabaudi, BP.IC
Abstract
The physiological balance provided by the regulation of the immune system is described as a critical point for the maintenance of homeostasis between specialized cells and cytokines. Thus, the function of inflammatory cytokines is well defined, among which the IL-12 family is known for its role in T helper lymphocytes. The IL-12 family consists of heterodimers that form five cytokines des…
- Evaluation of the role of CD8+ T lymphocytes in recognition of proteins expressed in reticulocytes infected with Plasmodium vivax, BP.DD
Abstract
In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of . The current research program includes three projects around a maintheme, which is "Immunological mechanisms of host resistance and disease in Malaria". I…
(Only some records are available in English at this moment)
- Generation and genotyping of transgenic animals (Cre-Lox System) for use in experimental models, BP.TT
- Generation and genotyping of transgenic animals (Cre-Lox system) for use in experimental models, BP.TT
- Understanding the immune response to Leishmania infantum, BP.PD
Abstract
Visceral leishmaniasis (VL) is a disease caused by Leishmania infantum. The sandfly vector inoculates parasites in the skin, which disseminate to organs such as lymph nodes, spleen, liver and bone marrow, hindering the function of these organs and causing symptomatic disease. VL can be fatal if not treated. However, a large proportion of endemic individuals do not develop any disease. The…
(Only some records are available in English at this moment)
Scholarships abroad
- The role of dermal macrophages in the initial immune response against Leishmania infection, BE.EP.DR
Abstract
Leishmaniasis is a disease transmitted by sand fly bites into host's skin, therefore the immune response against the parasite is initiated early in the skin, even in visceral cases. Murine models have shown that immune responses against Leishmania are very diverse, and may depend on the parasite species, strains and/or mice background. This is especially true for the roles played by infla…
- Caspase-8 involvement in mediating efficient canonical NLRP3 inflammasome activation during infection with fungal pathogen, BE.EP.DD
Abstract
The fungus Paracoccidioides brasiliensis is sensed by the Toll-like receptors 2, 4 (TLR2, 4) and dectin-1. The fungal recognition by dectin-1 is essential for NF-kB activation and induction of the expression of pro-IL-1B. The expression, maturation and secretion of IL-1B are processes tightly controlled. A major inflammatory pathway involved in the release of this cytokine is the activati…
- Mechanisms that regulate the processing of IL-1a, IL-1b and their role during experimental Trypanosoma cruzi infection, BE.EP.PD
Abstract
The parasite Trypanosoma cruzi is agent causative of Chagas disease. This pathogen causes robust innate immune responses in immunocompetent hosts, resulting in the recruitment of mononuclear cells to the heart. The pattern recognition receptors (PRRs), including TLR-2, -4, -7, and -9, as well as the cytosolic receptor Nod1 recognize pattern molecular pathogen associated to T. cruzi and tr…
(Only some records are available in English at this moment)
Total / Available in English
| 5 / 5 | Ongoing research grants |
| 24 / 11 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 57 / 30 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 99 / 59 | All research grants and scholarships |
| Associated processes | |