CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Chemistry from the University of São Paulo (1977), Master's (1980) and Doctorate (1986) in Biochemistry from the Faculty of Medicine of Ribeirão Prêto- USP, post-doctorate in Bio-Organic Chemistry from the SUNBOR Institute in Osaka, Japan (1994-1996). He is currently Full Professor of Proteomics at São Paulo State University (UNESP). Has experience in the area of Biochemistry of Macromolecules, Protein and Peptide Chemistry, as well as Chemistry of Natural Products of animal origin; specialized in mass spectrometry of biological macromolecules. He has worked in the study of the structural and functional characterization of venomous arthropod toxins, in the metabolomic and proteomic analysis of glandular secretions of insects, in the study of the structural dynamics of proteins and peptides with spectroscopic techniques. He was President and Vice-President of the Brazilian Society of Toxinology; he was Vice-President of the Brazilian Proteomics Society. He was President of the Latin American Branch of International Society of Neuropeptides (INPS), and during 15 years he was a member of the Central Board of INPS. He is currently a member of the Board of the Brazilian Society of Mass Spectrometry. He is a CNPq researcher (level 1B); has about 300 published works. He received the BRMASS medal for his contribution to Mass Spectrometry in Brazil; and the ?Innovation Award -2020? granted by the International Association for the Advanced Materials (Sweden). He supervised 17 master's dissertations, 19 doctoral theses, and supervised 16 postdoctoral internships. He is currently Editor of Protein and Peptide Chemistry at the AMINO ACIDS journal (Vienna); Reviewer Editor of the journal Frontiers in Plant Science - Section of Metabolism and Chemodiversity; Associate Editor of the Journal Frontiers of Allergy, section of Drugs, Venoms & Anaphylaxis. Member of the editorial board of the journals: Scientific Report, Peptides, Amino Acids, Toxins Reviews, Open Journal of Spectroscopy, and Toxicon. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Treatment for bee stings |
| Death swarm |
| News published in Agência FAPESP Newsletter about the researcher |
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Nature offers us an impressive number of different types of biologically active peptides. In multicellular organisms there is a large number of different types of peptides with cell signaling functions, physiological regulation, immune defense, regulation of growth, homeostasis, reproduction, neurotoxicity, production of pain/analgesia, inflammation, among other functions this sense, anim…
The demand for novel natural products is an important source of inspiration for most of the active ingredients of drugs worldwide; thus, there is a growing interest for the use of analytical platforms for increasingly sophisticated quantitative and qualitative identification of natural compounds in a fast and efficient way. Among these technologies, the combination of high resolution liqu…
Many modem medicines currently prescribed were initially discovered in the nature. Despite the progresses in chemistry and in the development of sophisticated instruments used in the combinatorial synthesis of novel compounds, the scientists are still using the nature as source of inspiration for the development of novel drugs. A substantial fraction of medicines under therapeutical use n…
(Only some records are available in English at this moment)
Some taxons of angiosperms biosynthesize peculiar substances known as cyclotides. Research about this class of natural products in species of Brazilian biodiversity is a theme of cutting-edge scientific research, with few Brazilian research groups in this area. Cyclotideshave potent insecticidal, anthelmintic and molluscicidal activities, what makes believe thatits biological function is …
Orbital web-building spiders feature a set of abdominal glands composed of up to seven different types - major ampullate, minor ampullate, flagelliform, tubuliform, aciniform, pyriform and aggregate glands; which secrete different types of fibers. And despite the great interest in the mechanical-elastic properties of the silk fibers produced by the spiders, aiming their use in biomedical …
Insect venom hypersensitivity is one of the leading causes of anaphylaxis in Brazil. Despite the great diversity of clinically relevant species identified in the country, no venom individual components obtained from endemic species are available for diagnosis and immunotherapy of allergy. Molecular characterization of insect venom allergens and particularly of the B-cells linear epitopes …
(Only some records are available in English at this moment)
Insect venom often triggers hypersensitive reactions and anaphylaxis in untreated allergic patients. Precise diagnosis regarding the clinically relevant species is mandatory for the success of the venom immunotherapy (VIT), the only disease-curative treatment available. Peptide-based cross-reactivity among homologous allergens from different species represents a major challenge for the pr…
Orb-weaving spiders have evolved the ability to synthesize adhesive threads to enhance the efficiency of their chemical arsenal for catching, paralyzing and/or killing prey. These adhesive threads are present in the capture spiral of the orb-webs, coated by a viscous solution that covers the entire silk fibers in the shape of droplets, which contain many vesicles under suspension, entrapp…
Spider silk proteins are synthesized in the silk-producing glands, where the spidroins are produced, stored and processed into a solid fiber from a crystalline liquid solution. Despite great interest in the spider silk properties, that make this material suitable for biomedical and biotechnological applications, the mechanism of formation and spinning of the silk fibers has not been fully…
(Only some records are available in English at this moment)
| 9 / 6 | Completed research grants |
| 33 / 21 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 47 / 32 | All research grants and scholarships |
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