MS (1992) and PhD (1995) in Physiology from Universidade Federal de São Paulo. Currently Professor (2012-) at the Biomedical Sciences Institute, Universidade of São Paulo. Has experience in Cell and Molecular Biology, focusing in key aspects of muscle plasticity such as regeneration, hypertropy/atrophy and hormonal action in muscle. (Source: Lattes Curriculum)
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Skeletal muscle dysfunction results in inadequate control of homeostasis and particularly a significant skeletal muscle loss (sarcopenia) has a substantial negative impact in the senile fragility syndrome onset in aging. This syndrome is characterized by an increased mortality due an individual's lower ability to maintain vital functions and typical immunological response. Furthermore, we…
This project contains a series of proposals aiming to deepen the knowledge on cellular and molecular mechanisms that control skeletal muscle mass and regeneration. This knowledge is key to the future development of therapeutic strategies that can improve skeletal muscle viability, consequently increasing quality of life. Noteworthy, there are a number of key clinical conditions involving …
Proteasome dependent proteolysis is a key process in skeletal muscle atrophy. Nonetheless the role of proteasome dependent proteolysis in other aspects of skeletal muscle remodeling such as fiber type specification is not well known. Ongoing experiments out of another study from our group show that MuRF1/MuRF2 knock out mice fail to regenerate properly, by mechanisms involving deficient d…
(Only some records are available in English at this moment)
Pulmonary emphysema is a chronic and progressive inflammatory disease that causes dyspnea, exercise capacity limitation, sarcopenia and weight loss that affects 17% of the population in Brazil and 10% of the adult population in industrialized countries. The present study aims to evaluate the effect of a selective inhibitor of MuRF1 activity (Muscle-RING Finger Protein 1), the compound Myo…
This project was conceived from the thematic project FAPESP 2015 / 04090-0, in which the analysis of an RNAseq of the soleus muscle of immobilized rats and supplemented with leucine identified 47 differentially expressed genes, modulated by immobilization and attenuated by leucine, among the which HDAC4 (Histone Deacetylase 4) stood out for its responsiveness (for reference, we forward th…
This project aims to evaluate the impact of the Myomedix-205 compound on skeletal muscle mass in a post-traumatic osteoarthritis model generated by the section of the anterior cruciate ligament in mice. For this purpose, 18 animals will be used and divided into the following groups: control (surgically simulated), post-traumatic osteoarthritis, post-traumatic osteoarthritis and treatment …
(Only some records are available in English at this moment)
Mechanical ventilation (MV) is a life-saving intervention commonly used in intensive care units (ICUs) for patients who cannot independently maintain adequate gas exchange. However, long-term MV results in detrimental clinical effects, including skeletal muscle weakness and wasting. Ventilator-induced diaphragmatic dysfunction (VIDD) is the early and progressive loss of diaphragm muscle c…
Heart Failure with preserved ejection fraction (HFpEF, approximately 50% of all heart failure (HF) cases) is a complex syndrome, with high morbidity and mortality rates. This form of HF is frequently seen in patients suffering from co-morbidities associated with the metabolic syndrome, namely obesity, hypertension, diabetes mellitus and hyperlipidemia, suggesting that HFpEF is a systemic …
Skeletal muscle is a major target of thyroid hormone (T3), this hormone acts mainly through gene transcription modulation and it is known for inducing muscle proteolysis. Previously, we addressed the effects of T3 in the protein synthesis and degradation related pathways by microarray analysis. From these data, we have shown that high levels of T3 stimulate protein breakdown by ubiquitin-…
Muscle atrophy is well-thought-out as an important element for mortality and morbidity of patients. Thus, the development of approaches to reduce symptoms of atrophy and to improve muscle strength are one of the biggest defies in skeletal muscle research area. Our laboratory has investigated the anti-catabolic effects of leucine related with the control of skeletal muscle mass. Leucine (a…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 21 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 38 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 68 / 32 | All research grants and scholarships |
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CV Lattes
ORCID