DDS in Dentistry from Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara-SP, Brazil (1997), master's in Periodontology from Universidade Estadual Paulista Júlio de Mesquita Filho Araraquara-SP, Brazil (2002), Ph.d. in Pharmacology And Therapeutics from University of Calgary-AB, Canada (2004), Ph.d. in Periodontology from Universidade Estadual Paulista Júlio de Mesquita Filho Araraquara-SP, Brazil (2005), and Pos-doctorate in Mucosal Inflammation at the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary-AB, Canada (2007). Professor at the Department of Stomatology, Discipline of Periodontology, Faculty of Dentisty, University of São Paulo, São Paulo-SP, Brazil. Professor of the MSc and PhD Program in Dental Science at FOUSP. Main interests: Pathogenesis of Periodontal Disease, Bi-directional association between periodontal disease and systemic conditions, and Advanced therapies in Periodontology. Specifically, studies the pathogenesis of periodontal disease and the effect of systemic conditions or modulatory therapies on the immune and inflammatory host responses. (Source: Lattes Curriculum)
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Recent efforts in periodontal treatment have focused on regenerative approaches based in cells. The membranes have gained full attention on the repair/ regeneration of periodontal defects due to their ability to allow osteoblastic proliferation and to support the mineralized matrix formation. The obtainment of the cell sheets through the detachment of the cell layer from the culture dish …
Protease activated receptor 1 (PAR1) activation by thrombin can play an important role on periodontal tissue homeostase and healing. A recent study from our group has shown an increased expression of PAR1 in gingival crevicular fluid cells of chronic periodontitis patients after periodontal treatment, and that PAR1 expression is associated with decreased levels of inflammatory biomarkers.…
(Only some records are available in English at this moment)
The regeneration of periodontal tissues lost through periodontal disease has been sought through biological solutions since the current therapeutic alternatives available are not completely predictable and satisfactory. Periodontal ligament stem cells (PDLSCs) are able to differentiate into cementoblasts/osteoblasts, adipocytes and collagen-forming cells, contributing to periodontal tissu…
Periodontal disease is highly prevalent and has as a characteristic the reabsorption of the periodontal ligament, cementum and alveolar bone. The regeneration of damaged tissues and organs is considered the ideal outcome of a treatment and has been sought through biological solutions once that traditional methods used for the treatment of bone defects have presented limitations. In this w…
Periodontitis is defined as a chronic inflammatory disease that results in the destruction of periodontal tissue support formed by cementum, alveolar bone and periodontal ligament. Such destruction is due to the persistent presence of specific microorganisms in periodontal tissues. Studies indicate that bacterial proteases have the ability to modulate the immune-inflammatory response of t…
(Only some records are available in English at this moment)
Maresins (macrophage mediators in resolving inflammation) are a family of specialized proresolving mediators of macrophage origin. These mediators are biosynthesized via initial lipoxygenation and molecular oxygen insertion at the carbon 14 position of docosahexaenoic acid (DHA) followed by epoxidation and oxygen incorporation at the carbon 7 position from a molecule of H2O. This research…
The association of Protease-activated receptor 2 (PAR2) and periodontitis was first suggested by in vitro studies which demonstrated that osteoblasts, oral epithelial cells and human gingival fibroblasts can express PAR2. Furthermore, it was observed that a selective agonist of PAR2 causes gingival granulocyte infiltration in rats and PAR2-deficient (PAR2-/-) mice show less inflammation r…
| 7 / 6 | Completed research grants |
| 10 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 19 / 16 | All research grants and scholarships |
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