bachelor's at Ciencias Biologicas from Pontifícia Universidade Católica de Campinas (1990), master's at Biochemistry from Universidade de São Paulo (1992) and doctorate at Biochemistry from Universidade de São Paulo (1996). He is currently coordenador do curso de pós-graduação at Universidade Federal de São Carlos. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: bioluminescencia, luciferases, lampyridae, phengodidae and elateridae. (Source: Lattes Curriculum)
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Bioluminescence, the emission of cold light by living organisms, has been the subject of many multidisciplinary studies involving physics, chemistry and biology, resulting in important scientific discoveries and biotechnological applications in the last century. It can be considered as one of the signatures of life, and for this reason has been used as an excellent bioindicator at the mol…
Bioluminescence, the emission of cold light by living organisms, has been the subject of many multidisciplinary studies involving physics, chemistry and biology, resulting in important scientific discoveries and biotechnological applications in the last century. It can be considered as one of the signatures of life, and for this reason has been used as an excellent bioindicator at the mol…
Not only is the elucidation of the Orfelia system likely to enable new bioanalytical tools, this bilateral project is also expected to benefit both the research gropps and associated graduate programs of Vanderbilt University and the Federal University of São Carlos, with the exchange of qualified human resources in the field of bioluminescent applications. (AU)
Bioluminescence in insects is found mainly in Coleoptera and Diptera. In Beetles of the superfamily Elateroidea, bioluminescence involves the same bioluminescence system with luciferins and luciferases well characterized. Beetle luciferin is a benzothiazolic compound, however, its biosynthetic origin remains unknown. The lanterns of bioluminescent beetles probably evolved from extensions …
Beetle luciferases arose from AMP-ligases. Because they display two catalytic functions, AMP/CoA-ligase and oxygenase, they constitute ideal models to investigate the structural and functional evolution of new catalytic functions in enzymes. Furthermore, because their biotechnological importance as bioanlaytical reagents and as reporter genes, such knowledge about structure, function and …
(Only some records are available in English at this moment)
Bioluminescence, the light emission in living organisms for signaling purposes, has several biotechnological and multidisciplinary applications. Luciferases are the responsible enzymes for catalyzing the light emission through the substrates oxidation (luciferins). In insects, bioluminescence is found in only three orders: Collembola, Diptera and Coleoptera. The bioluminescent system best…
Coleoptera species exhibits a wide range of visual displays, such as cuticle colors and bioluminescent signals, which arise from variation of sclerotization and pigmentation processes. Some evidences indicate the relation between intermediaries of sclerotization and pigmentation pathways and luciferin synthesis. Recently, transcriptome analysis of Malpighian tubules and fat body of Zopho…
Several luciferases of coleopteran species have been cloned by our group in the past few decade, however, many of them remain unknown as its primary structure and functional and evolutive aspects. Considering the phengodid luciferases were the least studied and with fewer enzymes cloned until now, its cloning and characterization is of the great importance, whereas the wide range of speci…
Lightbug luciferases emit light in the yellow-green region and their spectra are sensitive to pH and heavy metals. In recent decades firefly luciferases have been extensively used in ATP bioanalyses, cell viability, enzyme assays, and their genes have been employed as the most popular reporter genes for studying gene expression, biosensors and bioimaging. Recently, our group identified th…
Luciferases are the enzymes responsible for the production of bioluminescence in different organisms like bacteria, fungi, coelenterates, annelids, fish and insects. The beetle luciferases are among the most studied and used for biotechnological purposes. Many of these enzymes do not undergo post-translational modifications. However, some luciferases are glycosylated. Some insect lucifera…
(Only some records are available in English at this moment)
Beetle luciferases are responsible for the production of different bioluminescence colors from green to red using the same firefly D-luciferin. Some luciferin analogues such as 6´amino-analogues can extend the range of bioluminescence colors. Among several beetle luciferases that have cloned and been studied, Phrixothrix hirtus (PxRE) railroadworm luciferase is still the only one that nat…
Bioluminescence, the light emission produced by living organisms, has been widely found in terrestrial habitats in Elateroidea superfamily. The mechanism of light production in this superfamily is well known, however studies about genome organization and size are not discussed yet. The functional genomic projects are helping to identify important structural and functional elements of geno…
Bioluminescence, the emission of visible light by living organisms, is widely used in biosensors. Firefly luciferases genes are among the most used reporter genes in bioluminescent biosensors. Firefly luciferases are pH-sensitive displaying a large red shift at acid pH, a property that has been considered a useless for most applications. However, currently intracellular pH-biosensors are …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 14 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 35 / 26 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 60 / 49 | All research grants and scholarships |
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CV Lattes
ORCID