CV Lattes
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Ministério da Educação (Brasil). Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
master's at from Universidade Federal do Rio Grande do Sul (1997) and ph.d. from Princeton University (2004). Has experience in Microbiology, focusing on Virology, acting on the following subjects: ad169 hcmv, bac, bacterial artificial chromosome, west nile virus, molecular biology and virus-host interaction. (Source: Lattes Curriculum)
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Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive) phase. HCMV lytic infection occurs in a wide range of terminally differentiated cell types. HCMV latency has been less well studied, but one characterized site of late…
Kallikreins (KLKs) are serine-proteases with tryspsin-like or chymotrypsin-like specificity. The KLK family is composed of 15 members, named as KLK1 to KLK15 comprising the largest protease genes cluster, with structural homology of approximately 40%. The KLKs are related with diverse physiological functions, such as regulatory mechanisms of skin desquamation, formation of tooth enamel, r…
The Human Cytomegalovirus (HCMV) is a ubiquitous infectious agent of high prevalence worldwide. In healthy individuals, the infection is normally asymptomatic, however, in cases of immunosuppression the virus can be a life threatening agent. Recent findings demonstrate a relationship between HCMV and cancer. The virus has been detected in different cancer types, especially in glioblastoma…
Human cytomegalovirus (HCMV) is an important viral pathogen that causes a variety of diseases in imunocompromised individuals and newborns that can culminate in death. Recent evidences indicate that HCMV is involved in tumor progression. Studies demonstrated that the viral DNA and proteins are present in many types of cancer tissues; viral proteins are able to interfere with cell cycle, a…
Human Cytomegalovirus (HCMV) belongs to the Herpesviridae family,Betaherpesvirinae subfamily, which includes neurotropic viruses, with long replicative cycle and restricted species specificity. HCMV is an agent with high worldwide prevalence endowed with an exceptionally large arsenal of coded proteins which evade the host's innate and adaptive immune defenses, promoting viral persistence…
Abstract: The investigation of the role o Human Citomegalovirus (HCMV) in tumor malignancy is crucial due to its oncomodulatory effects. Like other hespervirus HCMV become latent in infected individuals and has the ability to reactivate in cases of immunodeficiency, such as cancer patients. This study aims to evaluate the resistance of HCMV infected and uninfected glioblastoma tumor cells…
The Human Cytomegalovirus (HCMV) is a ubiquitous agent highly prevalent worldwide. HCMV is able to persist in a latent stage in the host for life and can cause serious diseases in immunosuppressed and newborns. It is known that during latency various cellular proteins are expressed in order to avoid immune survailance. However the molecular mechanisms of establishment of latency and r…
| 1 / 1 | Ongoing research grants |
| 6 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 9 | All research grants and scholarships |
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