CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade de São Paulo (1999), master's at Odontology from Universidade de São Paulo (2003) and ph.d. at Biochemistry from Universidade Estadual de Campinas (2005). Has experience in Biochemistry, focusing on Enzymology, acting on the following subjects: enxerto xenogênico, biomateriais, enxerto ósseo, fluoride and reparo ósseo. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Considered quite aggressive and with a worse prognosis, triple negative breast cancer (TNBC) corresponds to about 10 to 24% of breast cancer cases in women, resulting in lower survival and metastases to various organs. In this scenario, enzymes such as matrix metalloproteinases (MMPs) are involved in metastasis, being responsible for cleaving extracellular matrix components, allowing coll…
Abstract: In recent years, new therapies studied by bone bioengineering have been developed with the purpose of promoting bone repair defects. The creation of constructs composed of bone-substitutes, growth factors and/or mesenchymal stem cells (MSCs), emerge as a promising strategy in the treatment of these defects. Our propose is evaluate in vitro and in vivo the use of a porous hydroxy…
Angiogenesis and osteogenesis are coupled during skeletal development. Endothelial cell and bone cells secrete various factors that help them to communicate with each other to establish proper bone homeostasis. Leukotriene B4 (LTB4) is a bone degrading factor, secreted in arthritis like inflammatory conditions by various cell types including bone cells such as osteoblast and osteoclast. A…
The therapeutic use of medicinal plants for prevention and maintaining health is growing daily, and this increase may be related due to existing a natural product that does not provide harm beliefs. However, for proper use of medicinal plants is vital knowledge of its active components and their toxic and therapeutic potential. Some applications in folk medicine for leaves Qualea grandifl…
(Only some records are available in English at this moment)
Triple-negative breast cancer (TNBC) is an invasive, aggressive, and recurrent tumor subclassification among the female population. Due to the non-expression of important hormone receptors, there are difficulties both in the prognosis and in the treatment of patients diagnosed with TNBC. Chemotherapy, in the absence of targeted therapies, is the most used method in these cases. Seeking be…
Diabetes mellitus (DM) is a disease of great social impact, and the prospects are that its prevalence will increase even more, due to people's lifestyle. Among the different types of diabetes, type 2 (DM2) is the one with the highest prevalence (90%). The pathogenesis of DM2 is complex, and is involved with a progression of insulin resistance in the liver and peripheral tissues, accompani…
Breast Cancer is the most common among women, with about 10 to 24% presenting in the triple negative (TNBC) invasive form, resulting in shorter survival and worse prognosis, including metastases to several organs. Enzymes such as metalloproteinases (MMP) are involved in metastasis, being responsible for the cleavage of extracellular matrix components allowing collagen degradation, as in t…
Acquired Immunodeficiency Syndrome (AIDS) is considered a risk factor for osteoporosis. Among the many causes that lead seropositives to a lower bone density, there is the use of antiretroviral drugs, especially Protease Inhibitors (PI), such as Lopinavir/Ritonavir (LPV/RTV). In vitro, it was able to decrease the osteogenic activity of primary bone cells, with significantly lower levels o…
Cancer is the leading cause of death in developed countries and the second largest in developing countries. In 2018, approximately 600 thousand new cases and approximately 250 thousand deaths were registered in Brazil, demonstrating a public health problem. Among the various types, breast cancer and osteosarcoma are of serious severity, with a high mortality rate. Therefore, the search fo…
Deregulation of normal cell mechanisms leads to the development of neoplastic processes, some of these processes are related to resistance to cellular apoptosis, proliferation signaling of the tumor mass, induction of angiogenesis, capacity for tissue invasion and metastasis. Tumor cells are commonly exposed to stress conditions, environmental factors and deregulation in oxidative metabol…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 9 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 24 / 24 | Completed scholarships in Brazil |
| 37 / 37 | All research grants and scholarships |
| Associated processes | |