CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the University of São Paulo (FMUSP)(1990), Residency in Endocrinology at Hospital das Clínicas - FMUSP (1994) and Preceptorship at HCFMUSP (1995). She completed her PhD in Endocrinology at FMUSP (1999) and Post-doctoral in Endocrinology at the University of São Paulo (2004). She is currently the head of the Thyroid Unit of the Endocrinology and Metabology Discipline at Hospital das Clinicas-FMUSP and head of Cellular and Molecular Endocrinology Laboratory (LIM / 25) -FMUSP. She is a collaborating professor at Faculty of Medicine - USP, working in the MEdicine School. She is a supervisor in the FMUSP at Postgraduate Program and coordinator of the Postgraduate Discipline. She has experience in the area of Endocrinology, working mainly on the following topics: 1. Autoimmune thyroid diseases, such as Hashimoto's thyroiditis and Graves' disease; 2. Thyroid diseases before, during and after pregnancy; 3. Thyroid diseases associated with medications and other illnesses; 4. Clinical and molecular diagnosis, follow-up and treatment of thyroid nodules, goiter and thyroid cancer; 5. Molecular diagnosis of congenital hypothyroidism She is Endocrinology Specialist obtained from the Society of Endocrinology and Metabology (SBEM). She is a member of the American Thyroid Association, Latin American Thyroid Society, Endocrine Society and SBEM. She is an advisor in Endocrinology and Responsible for the Endocrinology Committee at Diagnostics of the Americas (DASA). (Source: Lattes Curriculum)
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Graves' disease (GD) is the main cause of hyperthyroidism, due to the presence of immunoglobulins, IgG1 subclass, directly against the TSH receptor (TSHR). Patients with GD present antibodies against TSHR (TRAb), divided into stimulators (TSI) and blockers and apoptotic (TBI). The balance between the blocking and inhibitory antibodies determines the degree of thyroid function. With the de…
Graves' disease (GD) is responsible for 60-80% of patients affected by hyperthyroidism. GD has autoimmune characteristics, with production of autoantibodies produced by B lymphocytes against thyroidantigens, such as thyroperoxidase, thyroglobulin, TSH receptor, sodium-iodine symporter. Genetic and epigenetic factors have roles in triggering GD, like C TLA4 and TG genes, as well as substan…
The main role of the thyroid gland is the production of T3 and T4 that are essential for development and regulation of several functions in the body. Congenital hypothyroidism (CH) is a systemic metabolic disorder, with insufficient production of thyroid hormones in the neonatal period. HC can be caused by embryonic development defects of thyroid gland (dysgenesis) or in the hormones synt…
(Only some records are available in English at this moment)
Goiter, an enlargement of the thyroid gland, is a common disease and can present as multiple areas of nodularity, characterizing multinodular goiter (MNG). Chronic iodine deficiency is the well-known cause of MNG. In iodine sufficient populations, MNG is more common in women and older patients. Rare germline mutations are associated to goiter development and the most recently found were a…
The term Goiter is commonly used to describe the clinical changes resulting from the increased thyroid volume. Goiter may occur endemically, due to iodine deficiency, or sporadically, in places that are already iodine sufficient. The Non-Toxic Multinodular Goiter (NTMG) is defined with an increased thyroid volume and TSH and thyroid hormone levels are within normal range. The disease evol…
Graves' disease (GD) is a classic example of hyperthyroidism caused by autoimmune thyroid disease (AITD). It is multifactorial, with genetic predisposition, followed by environmental factors that trigger humoral and cellular immune responses against the thyroid tissue itself. The development of antibody to the TSH receptor (TRAb) stimulates thyroid follicular cells, both in the production…
(Only some records are available in English at this moment)
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