Nurse bachelor at Universidade Estadual de Campinas, Unicamp (1985), master in Biochemistry at Unicamp (1988) and Ph.D in Biochemistry at Universidade de São Paulo (1993); Full professor in Biochemistry, Unicamp (2010). Has experience in Byophysics, Biochemistry and pharmacy, focusing on Drug delivery and Biomimetic systems, focusing the interaction of active molecules (local anesthetics, anticancer drugs) with carriers such as liposomes, nanostructured lipid carriers, cyclodextrins). (Source: Lattes Curriculum)
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Metabolomics study the quantitative changes in low molecular weight metabolites that occur in biological samples such as biofluids, cells and tissues. Nuclear Magnetic Resonance (NMR) and Mass spectroscopy are the two main techniques in metabolomic studies. This request is intended to find the financial support for a short-time visit (15 days, from October 8th to 22th 2023) of Dr. Thelma …
Nanostructured lipid carriers (CLN) are suitable for the encapsulation of hydrophobic drugs, offering a series of advantages over other drug-delivery carriers such as: biocompatibility, biodegradability, non-immunogenicity, relative low cost, no requirement of organic solvents and scalability. Aiming to stablish a collaborative research network between the Biomembranes laboratory (Unicamp…
The aim of this project is to facilitate the cooperation of 3 different research groups, from UNICAMP, USP and University of Copenhagen, in the quest of developing new antimicrobials, nanoformulated (with different drug-delivery carriers) and encapsulated in mesoporous silica/clays, to generate novel pharmaceutical formulations of increased antimicrobial activity against resistant pathoge…
The pilot freeze dryer is essential to the development of lyophilized parenteral formulations that are reproducible, traceable, scalable, without contaminants and stable. Currently there is no pilot freeze dryer available for drug development in Unicamp. The main focus of our research group for years is the parenteral drug formulation, aimed not only at academic research but also the prod…
(Only some records are available in English at this moment)
Breast cancer is the most common solid neoplasm in the world and the most diagnosed among women since the 1990s, affecting several age groups, and being the second most common cause of death, due to cancer, among women. Doxorubicin (DOX) is an antineoplastic antibiotic from the anthracycline group, isolated from fungal cultures of Streptomyces peucetius. DOX is used to treat breast cancer…
The use of Nanostructured Lipid Carriers (NLC) in drug delivery has attracted attention in last years. Developed in the end of the 90's, the core of NLC is composed of a mixture of solid lipid and liquid lipids, which allows for high drug upload and increased stability of the nanoparticles. However, the immiscibility between NLC excipients and between excipients and incorporated drugs can…
Of the malignant tumors registered in Brazil, skin cancer is the most frequent and corresponds to about 30% of the cases. Melanoma is a type of skin cancer that, despite its low incidence (3% of malignant neoplasms), is the most aggressive form of skin cancer given its high metastatic potential (mainly brain), high mortality (80%) and resistance to therapy with chemotherapeutic agents. Th…
The encapsulation of Local Anesthetics (LA) in ionic gradient liposomes (IGL) has been shown to increase the time of analgesia and decrease the side effects, by maintaining the drug in the site of action for a longer time. Intradermal administration of IGL prepared with (NH4)2SO4 in a human volunteer achieved up to 19, 38, and 48 h of successful anesthesia with 0.5, 1, and 2% bupivacaine …
Pain control in burn injuries and their treatment remains a difficult challenge. Opioid therapy, although often used, has several limitations. An alternative to meet such demand is the application of local anesthetics, which are potential drugs for the treatment of such injuries. Bupivacaine is the local anesthetic most used worldwide in surgeries and postoperative periods, with a time of…
(Only some records are available in English at this moment)
In the pharmaceutical field, several variables and processes can affect the properties and characteristics of new formulations. Therefore, the use of powerful algorithms during data analysis allows adoption of proper mathematical models as a strategy to reduce the complexity of the subject and increase our knowledge of the overall system. During this BEPE, ComDim algorithm will be used to…
Local anesthetics (AL) are drugs widely used in medical and dental clinics being capable of reversibly blocking the painful stimulus without loss of consciousness. However, in some cases AL may not have the desired effects, such as in inflamed tissues. To circumvent this situation, ALs can be encapsulated in nanostructured lipid carriers (NLC) composed of synthetic or natural excipients i…
Local anesthetics (LAs) are often used in medical practice when it is necessary to numb parts of the body. Although desirable, local anesthetics cannot guarantee the selective blockage of nociceptive fibers causing adverse reaction (motor and autonomic blockage). Recently, it was reported that the application of local anesthetic followed by capsaicin leads to a selective increase in senso…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 18 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 45 / 21 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 70 / 41 | All research grants and scholarships |
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CV Lattes
ORCID