CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Biomedicina from Universidade Federal de São Paulo (1980), master's at Microbiology from Universidade Federal de São Paulo (1985) and doctorate at Microbiology from Universidade Federal de São Paulo (1990). Has experience in Microbiology, acting on the following subjects: p brasiliensis, paracoccidioides brasiliensis, gp43, polimorfismo and p. brasiliensis. (Source: Lattes Curriculum)
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Extracellular vesicles (EVs) are membranous components involved in a non-classical secretion mechanism reported in all kingdoms. EVs carry to the extracellular environment hundreds of molecules in a concentrated and protected way, thus promoting a sophisticated kind of distant cell signaling. Our group pioneered the description of EV proteins, lipids, oligo and polysaccharides from Paraco…
Paracoccidioides species and Histoplasma capsulatum are medically important thermodimorphic fungi and will be used as model systems in this project. The cell wall, which is the main fungal interface with the host, is constituted mainly of structural polysaccharides, specifically glucans, chitin, and galactomannan. This project aims to study, under different stress conditions, the global e…
We aim at using the fungal pathogens Paracoccidioides brasiliensis and Cryptococcus neoformans as model systems to the study of membranous vesicular structures (exosome-like) and of cell wall components. We intend to isolate and characterize the vesicles, to determine their composition in comparison with cell wall fractions, to evaluate their immunomodulatory potential and the role of mon…
(Only some records are available in English at this moment)
We have previously shown in Paracoccidioides brasiliensis extracellular vesicles carrying immunogenic epitopes containing alfa-linked galactopyranosyl residues (alfa-Gal), which were also localized on the cell-wall and intracellular vacuoles of the fungal yeast cell. alfa-Gal epitopes produced intense reaction in ELISA with anti-alfa-Gal antibodies from chagasic and paracoccidioidomycosis…
Extracellular vesicles (EV) have recently been described in pathogenic fungi. In our laboratory, we have previously reported Paracoccidioides brasiliensis EV protein and lipid content, besides carbohydrate epitopes. Nowadays, we also have results of the RNA and polysaccharide EV content. Fungal EV carry components that potentially interact with the host, stimulate the immune system and a…
Paracoccidioides species and Histoplasma capsulatum are medically important thermodimorphic fungi. The cell wall, which is the main interface of the fungus with the host, is constituted mainly of structural polysaccharides, which are remodelled during stress conditions. This project aims to study, under different stress conditions, the global expression regulation of transcription factors…
(Only some records are available in English at this moment)
Histoplasma capsulatum is a medically important thermodimorphic fungal species in North and Latin America. The cell wall, which is the main interface of the fungus with the host, is composed mainly of structural polysaccharides, which are remodeled during stress conditions. Many fungal transcription factors have been involved in the response to different stress conditions, including Mns2/…
Molecules secreted to the cell surface or to the extracellular environment are obvious targets to participate in host-parasite interaction. Release of membranous vesicles is a conserved process in both prokaryote and eukaryote cells. Fungal extracellular vesicles (EV) are important structures involved in the transport of virulence factors including numerous proteins, neutral lipids, glyca…
| 1 / 1 | Ongoing research grants |
| 12 / 6 | Completed research grants |
| 19 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 34 / 16 | All research grants and scholarships |
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