graduate at Ciencias Biológicas from Universidade de São Paulo (1977) and ph.d. at Bioquímica from Universidade de São Paulo (1982). Has experience in Genetics, focusing on Molecular Genetics and of Microorganisms, acting on the following subjects: reparo de dna, ultravioleta, mutagenese, reparo dna and xeroderma pigmentosum. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Subtle damage from the sun |
| Residuos bienvenidos |
| En lucha contra el sol |
| Welcome waste |
| Los sutiles daños causados por el Sol |
| Subtle damage from the sun |
| Inheritance outside the family |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The world population is getting older and older. Unfortunately, this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct, and stroke, which profoundly compromise the quality of life of the elderly. Age-related disorders are generally viewed as necessary evil. Our project challenges this dogma, as we propose that the…
The world population is getting older and older. Unfortunately, this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct, and stroke, which profoundly compromise the quality of life of the elderly. Age-related disorders are generally viewed as necessary evil. Our project challenges this dogma, as we propose that the…
The circadian clock is an internal timing mechanism, orchestrating diurnal variations in behavior, physiology and metabolism, aimed to best prepare us for daily recurring changes in our environment (i,e. the light/dark cycle). Evidence is increasing that uptake, metabolization and detoxification of chemicals is under control of the circadian clock and that, accordingly, the severity of to…
This project aims at expanding the facility's equipment park GENIAL (Genome Investigation and Analysis Laboratory) of CEFAP-USP (Facilities Center of Research Support at the University of São Paulo), providing the scientific university community and other national Institutes new equipment for next-generation sequencing, called Illumina NextSeq " 500 sequencing System, and a robot for auto…
(Only some records are available in English at this moment)
Cockayne Syndrome (CS) is a genetic neurodegenerative disease related to the impairment of the transcription-coupled repair sub-pathway (TCR-NER). The CSB protein acts directly on this repair subpathway and, therefore, CSB mutant cells are more sensitive to agents that cause DNA damage. The greater sensitivity of these cells to UV light, an agent that damage DNA, is well known, however, e…
DNA repair systems act on genome integrity maintenance upon exposure to internal and external mutagenic agents. Deficiencies in these systems may lead to premature aging and neurodegeneration in Cockayne syndrome (CS) patients. CS is a recessive autosomal disease caused by mutations mainly in ERCC6 and ERCC8 genes. Both genes codeproteins enrolled on the first step of transcription-couple…
Cokayne Syndrome (CS) is an autosomal recessive disease, which is characterized by neurodegeneration, CS patients are characterized by having sunken eyes, microcephaly, prominent jaws, erythematous dermatitis on sun-exposed skin, failure in the growth process and delay cognitive, in addition to neuronal loss, calcification, spasms and tremors. The cause of CS disease is related to mutati…
(Only some records are available in English at this moment)
Genetic defects in nucleotide excision repair (NER) result in syndromes whose patients have a high frequency of cancer and/or symptoms related to premature aging and neurodegeneration. In the case of mutations in the ERCC2/XPD gene, for example, mutations can lead to different pathologies, such as Xeroderma Pigmentosum (XP), Cockayne syndrome (CS) and Trichothiodystrophy (TTD), in which t…
People with Xeroderma Pigmentosum (XP), a rare autosomal genetic disease, have defects in the repair of DNA nucleotide lesions induced by Ultraviolet Radiation (UV), the Nucleotide Excision Repair (NER) pathway. XP patients are highly sensitive to solar radiation, showing skin lesions on minimal exposure to the sun, and high incidence of skin cancer compared to the general population. Stu…
DNA is a molecule that undergoes constant attacks of genotoxic agents, either of endogenous or exogenous origins. These interactions can generate lesions in DNA and subsequently mutations. To prevent such damage, our cells have several DNA repair mechanisms, which preserve the genome. People who have disabilities in these mechanisms have clinical pictures related to high frequency of tumo…
(Only some records are available in English at this moment)
Trichothiodystrophy is a progeroid syndrome related to Nucleotide Excision Repair deficiency, derived from a mutation in the ERCC2/XPD gene. Considering that the most important and more complex clinical feature of TTD is the neurodegeneration process and that the available cells we have are patients' fibroblasts in monolayer culture, the possibility to use a more appropriate and complete …
Temozolomide (TMZ) is the main drug used to treat gliomas, which causes DNA damage leading to cell death mainly as a consequence of processing of the primary damage O6-methylguanine (O6meG). Several mechanisms of resistance were described, and the ability of MGMT (O-6-methylguanine-DNA methyltransferase) to directly reverse O6meG in the DNA molecule is the most significant. Moreover, the …
Human genetic syndromes deficient in the Nucleotide Excision Repair (NER) pathway are known to display photosensitivity and neurological problems, such as xeroderma pigmentosum (XP). In Brazil, a few case-reports had described patients with these phenotypes, but genetic and molecular characterization data are scarce. In the current post-doc project, we are identifying mutations from Brazi…
R-loops are non B-DNA structures that are formed when a nascent RNA molecule anneals to a DNA template leaving a displaced single strand DNA. Those structures naturally occur in all organisms, but the lack of homeostasis leads to accumulation of those hybrids inducing genomic instability. There are several proteins involved in preventing the accumulation of those hybrids during the transc…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 54 / 20 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 121 / 41 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 10 / 10 | Completed scholarships abroad |
| 197 / 83 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID