Marcia Perez dos Santos Cabrera

• Abstract

  This collaborative work will evaluate known and designed mastoparan peptides and peptide/chitosan conjugates for the treatment of microbial and cancer diseases. Specifically, the following steps will be carried on: 1. Characterization of the peptide's and conjugates' cytotoxic activity toward different bacteria strains with clinical impact and human normal and cancer cells, particularly b…

  Antimicrobial, anticancer peptides and peptide/chitosan conjugates characterization by AFM (Atomic force microscopy), AP.R SPRINT

• Abstract

  One of the main advantages in the use of antimicrobial peptides in antibiotic therapy is the reduced chance of resistance development, since these peptides target the cell membrane phospholipid matrix. Mechanisms of the selective action found in some bioactive peptides are investigated as a means to orient structural optimizations that can enhance the therapeutic action and at the same ti…

  Peptide and chitosan conjugates with pharmacological potential: synthesis, prospecting of activity in membrane mimetic systems, and evaluation in cells, AP.JP

• Abstract

  One of the main advantages of antimicrobial peptides in antibiotic therapy is the reduced chance of resistance development, since these peptides target the phospholipid matrix of the cell membrane. Some of these peptides are also active against Leishmania, which is the causative agent of one of the neglected diseases according to WHO. The current therapies have serious shortcomings relate…

  Charge and hydrophobicity effects on the interactions peptides with potential leishmanicidal activity and lipid bilayers, BP.IC

• Abstract

  Starting with commercial chitosans modified to increase the solubility at physiological pH and reduce the molar mass, a conjugate with a loaded and small chain peptide will be obtained. The combination of route is performed via glutathione- chitosan compound and conjugating the peptide via the N-terminal. Additionally another peptide chain and greater hydrophobicity will be used in the co…

  New route for synthesis of conjugates peptide-chitosan: the effects of the peptide's hydrophobicity evaluated on model membranes interaction via zeta potential, BP.IC

• Abstract

  Therapeutic effects of antioxidants have been investigated for their role on prevention and treatment of several diseases, but few studies report on the interaction of these natural substances with membranes. Recently it has been identified that the antioxidant curcumin modulates lipid bilayer properties. Moreover this action was reported to be similar to the effects of other amphiphilic …

  Interactions of lipid bilayers and natural antioxidants, BP.IC

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