bachelor's at Farmácia from Universidade Estadual da Paraíba (2008), master's at Pharmacology from Universidade Federal de São Paulo (2010) and doctorate at Pharmacology from Universidade Federal de São Paulo (2015). Has experience in Pharmacy, focusing on Pharmacy, acting on the following subjects: huntington disease, autofagia, reações adversas a medicamentos, pacientes oncológicos and autophagy. (Source: Lattes Curriculum)
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Hepatocellular carcinoma (HCC) is a primary liver neoplasm that originates in hepatocytes caused by hepatitis B and C virus infections, which are the major etiologic causes of HCC, either through carcinogenesis or cirrhosis. Most of the patients undergoing therapy have the option of treatment with sorafenib, a drug-target multi-kinase inhibitor treatment; however, drug resistance is still…
Management of intracellular levels of macromolecules, as protein and lipids, is essential for the efficiency of cellular processes which include growth, stress response and cell survival. The obtained information will help to develop a useful working model to better understand quality control of intracellular lipids accumulation and protein aggregation, which may provide functional inform…
Metabolic diseases related to obesity are a major public health issue worldwide. Lipids are essential components of a cell providing energy substrates for cellular processes, signaling intermediates, and building blocks of biological membranes. Lysosomes play an important role in this recycling process that involves the recruitment of lipids to lysosomes via autophagy for their degradatio…
Alzheimer's Disease (AD) is one of the most studied neurodegenerative diseases, being a common cause of Dementia in the elderly. The hyperphosphorylated Tau protein is the neuron pathological hallmark for diseases called Tauopathies, such as AD, and consequently, may lead to cell death. Autophagy is crucial for neuronal homeostasis, since autophagic dysfunctions are related to abnormal ac…
Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. In previous studies, we showed the Nicotinic acid adenine dinucleotide phosphate (NAADP) as a potent Ca2+ mobilizing messenger in astrocytes, since NAADP releases Ca2+ from the endo-lysosomal system and this effect was mediated by the two-pore channels (TPCs), es…
In the past few years, the inositol triphosphate (IP3) and adenosine diphosphate ribose (cADPR) were well stablished as intracelullar messengers that interact with the IP3R and RyR, respectively. Recently, a novel second messenger was described, the NAADP (nicotinic acid adenine dinucleotide phosphate), which induces a significant mobilization of intracellular calcium (Ca2+). Evidences sh…
Although one of the most common and penetrant genetic risk factors for Parkinson Disease is mutation of the LRRK2 gene, the function of the LRRK2 protein is not entirely clear. Its multi-domain structure conferring protein-protein interactivity and enzymatic function suggests a complex mode of action. Yet potentially druggable signalling pathways downstream of LRRK2 are ill-defined. At th…
Autophagy is a catabolic process essential for the turnover of cytosolic proteins and organelles. It involves the formation of a double membrane structure known as the autophagosome around a targeted region of the cytosol. The Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger that in many cells releases Ca2+ from the endo-lysosomal system, this ef…
| 4 / 3 | Completed research grants |
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 9 / 8 | All research grants and scholarships |
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CV Lattes
ORCID