Abstract
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
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Paolo Di Mascio
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Tecnologia Biomédica from Université Catholique de Louvain (1987), bachelor's at Química Clínica from Université Libre de Bruxelles (Couvreur- De Mot) (1984) and doctorate at Tecnologia Biomédica from Universidade de Düsseldorf /Université Catholique de Louvain (1989). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: singlet oxygen, dna, dna, dna damage and mass spectrometry. (Source: Lattes Curriculum)
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Research grants
- Implementation Plan of the Technical Reserve for Institutional Infrastructure Financial Resources granted in 2019., AP.RT.INST
- Redoxome - Redox Processes in Biomedicine, AP.CEPID
Abstract
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
- Implementation Plan of the Technical Reserve for Institutional Infrastructure Financial Resources granted in 2016, AP.RT.INST
Abstract
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
- Multi-user equipment approved in grant 2014/25980-0: spectrofluorometer, AP.EMU
Abstract
Acquisition al the IQ_USP (CA) of spectrofluorometer equipment. This is currently critical to the continued development of competitive research at the frontier of knowledge. The technique is extremely important for research in chemistry and biochemistry with applications in agriculture, toxicology, health, among others. (AU)
- Multi-user equipment approved in grant 2014/25980-0: gas chromatography-mass spectrometry (GC-MS), AP.EMU
Abstract
Substitution al the Analytical Chemistry Instrumentation Facility at (IQ-USP) of GC next-generation MS spectrometry equipment. This is currently critical to the continued development of competitive research at the frontier of knowledge. The technique is extremely important for research in chemistry and biochemistry about structure and structural changes of molecules with applications in a…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Multifunctional fluorescence quantum dots as amplifiers for 1O2 generation and synergistic enhanced photodynamic therapy, BP.PD
Abstract
The development of multifunctional nanoplatform with integrated diagnostics and simultaneous local therapy, while evading the off-site problems, is highly desired for precise treatment. Singlet oxygen (1O2) is a highly reactive species used by the biological system as a defensive tool against obnoxious agents and Cancer therapy due to its ready interaction with unsaturated lipids, protein…
- Singlet oxygen generation by different photosensitizers excited by nanoparticle presenting upconversion and biological applications, BP.DD
Abstract
Electronically excited molecular oxygen at the singlet state 1Δg (1O2) is known for its reactivity in proximity to high electron density organic molecules. 1O2 reactions with biomolecules have been studied in recent decades as a source of study of lesions related to cytotoxic and pathophysiological processes, which is indicative of the importance of studying this molecule in complex syste…
- Determination of 6-thioguanine in the DNA of epithelial cells, BP.IC
Abstract
The thiopurines azathioprine, 6-thioguanine (6-TG), and 6-mercaptopurine (6-MP) are used as immunosuppressors in transplanted patients, and for treatment of inflammatory diseases, such as rheumatoid arthritis and systemic lupus. These drugs are metabolized by the purine salvage pathway, converted into thioguanine nucleotides and then incorporated in DNA as 6-TG. Recent studies reveal that…
- The signaling role of tryptophan tricyclic hidroperoxides in smooth cells of vascular epithelium, BP.PD
Abstract
In 2008, two isomeric tryptophan hydroperoxides (cis and trans WOOH) were characterized by our group as the main singlet oxygen tryptophan oxidation products. These peroxides break down into alcohols, formylkynurenine and kynurenine. In 2010, it was proposed that kynurenine is a relaxing endothelial factor that aids in controlling blood pressure. Under inflammatory conditions, the enzyme …
- Mechanistic study of singlet oxygen formation by tryptophan and tyrosine peroxides in the context of damage to biomolecules by oxidants, BP.IC
Abstract
Damage to biomolecules (eg proteins) can be generated by extremely reactive oxidants, such as the hydroxyl radical (* OH), or by less reactive, and therefore more selective oxidants such as peroxyl, hypochlorous acid (HOCl) and oxygen radicals singlet (O2(1g)). HOCl, for example, plays an important role in defense against pathogens. However, this same molecule is strongly related to the …
(Only some records are available in English at this moment)
Scholarships abroad
- Upconverting nanoparticles for thermometry and singlet oxygen sensing applications in biological imaging, BE.EP.PD
Abstract
Trivalent rare earth ions (RE3+) doped nanoparticles can exhibit upconversion phenomenon. This process consists in excitation of the material with two or more photons and, subsequently, emission of a higher energy photon. In this way, it is possible to use an excitation source in the biological window region and obtain UV-Visible-NIR emissions. The advantages of upconverting nanoparticles…
Total / Available in English
| 2 / 2 | Ongoing research grants |
| 17 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 29 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 51 / 25 | All research grants and scholarships |
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