Manoel João Batista Castello Girão

• Abstract

  The uterine and vaginal agenesis, also know as Syndrome Mayer-Rokitansky-Kuster-Hauser (SMRKH) is a congenital malformation that, although rare, carries important clinical and psychological repercussions, due to the impaiment of sexual activity and reproductive life. The treatment for this disease is divided in to bloodless and surgical methods and consists in the construction of a neovag…

  In vitro autologous vaginal tissue culture development: treatment improvements in Mayer-Rokitansky-Kuster-Hauser (SMRKH) syndrome patients, AP.R

• Abstract

  Many differences are known when comparing the expression of several proteins in the endometrium of women with endometriosis with that of healthy . This study aims to identify differences in gene expression when comparing the endocervical epithelium of women with the diagnosis of deep endometriosis with women without the disease. The purpose is the establishment of a non-invasive test fo…

  Analysis of gene expression in endocervical epithelium of women with and without deep endometriosis, AP.R

• Abstract

  In breast cancer, stromal cells include resident adipocyte and fibroblast, a wide range of recruited hematopoietic cells, and newly formed blood vessels qith their associated cells. Dynamic and reciprocal communication between epithelial and stromal compartments occurs during breast cancer progression. (AU)

  Heterotypic culture: the cross-talking between epithelial tumor cells, mammary stroma, macrophages and platelets in breast cancer: the release of proteolytic enzymes and signaling of toll-like receptors, AP.R

(Only some records are available in English at this moment)

• Abstract

  Breast cancer is a multifactorial disease heterotypic which for a long time researchers have tried to extract its complexity with cultivation of epithelial cells. This system enabled the advancement of genetics and molecular biology of cancer. However, cultivation of single immortalized breast epithelial cells is insufficient to mimic the tumor microenvironment. There is evidence that in …

  Heterotypic culture: The Cross-Talking between epithelial tumor cells, mammary stroma, macrophages and platelets in breast cancer: the release of proteolytic enzymes and signaling of Toll-like receptors, BP.PD
• Description and evaluation of experimental models for uterine transplantation in rabbits, BP.PD

• Abstract

  Endometriosis is a chronic gynecological disorder defined as the presence of endometrial tissue within extra-uterine sites. The initiation and progression of the disease seems to be related to the presence of endometrial stem cells in regurgitated menstrual fluid and to the epithelial to mesothelial transition (EMT) process. A three-dimensional in vitro culture system which we have previo…

  Endometriotic implants establishment: an in vitro model applying World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonisation Project (EPhect) Standards, BE.EP.PD

• Abstract

  Breast cancer (BC) is the most frequently diagnosed cancer in women, affecting one in eight women. Despite improved treatment strategies, this disease has become the focus of numerous scientific papers in order to introduce new techniques, drugs and more effective treatments. Endothelial cells (ECs) line blood vessels to supply oxygen and nutrients to tissues. Abnormal blood vessel growth…

  The role of PFKFB3 in angiogenesis: a model to study breast cancer, BE.EP.PD