Professor of the Department of Basic and Oral Biology at School of Dentistry of Ribeirão Preto, University of São Paulo (FORP-USP). Graduated in Dentistry from the FORP-USP (1999), MSc and PhD in Biological Sciences (Pharmacology) from the School of Medicine of Ribeirão Preto, University of São Paulo (2003 and 2004). Postdoctoral internship with the Department of Cell Biology of the University of Massachusetts Medical School (2008-2010). Member of the editorial board of the Journal of Dental Research. Experience in Dentistry, with an emphasis on cell biology, working on the following topics: cell signaling in bone tissue and regenerative medicine (tissue engineering and cell therapy) of bone tissue. (Source: Lattes Curriculum)
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Osteocytes are the most abundant cells in bone tissue with key role for the skeleton function. They are derived from the osteoprogenitor lineage, exhibit a dendritic morphology and are embedded by the mineralized matrix during the bone formation process. Osteocytes regulate the activity of osteoblasts and osteoclasts through the secretion of factors that modulate several signaling pathway…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
The osseointegration of titanium (Ti) implants is based on bone remodeling, which involves a balance between bone tissue formation by osteoblasts and tissue resorption by osteoclasts. Our group has shown that a Ti surface with nanotopography obtained by chemical conditioning with H2SO4/H2O2 solution is capable of inducing osteoblast differentiation under both osteogenic and non-osteogenic…
The titanium surface with nanotopography, generated by H2SO4/H2O2 treatment, exhibits high osteogenic potential thanks to its ability to modulate signaling pathways involved in osteoblast differentiation such as integrin and bone morphogenetic protein (BMP) signals. Considering the relevant participation of Wingless-Type mouse mammary tumor virus [MMTV] Integration Site (Wnt) signaling pa…
(Only some records are available in English at this moment)
Bone tissue has a high capacity for regeneration, but in several situations, the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared to the available treatments. However, many molecular, cellular and tissue character…
Cell therapy using mesenchymal stem cells (MSCs) is a promising strategy to treat large bone defects and the study of molecules that act on these cells to favor bone regeneration is essential in this context. Our research group have demonstrated that the extracellular matrix protein agrin participates in osteoblastic differentiation, probably by regulating BMP and Wnt signaling pathways, …
Cell therapy is one of the strategies of the regenerative medicine with potential for the treatment of large bone defects mainly using Mesenchymal Stem Cells (MSCs) and the study of molecules that act on these cells to favor bone regeneration is essential in this context. Among these molecules, the extracellular matrix protein agrin, which is involved in several biological processes, was …
The extracellular matrix protein agrin acts on the regulation of neuromuscular synapses, signaling in immunological synapses and cardiac tissue regeneration. Furthermore, agrin plays a relevant role in skeletal development; however, it has been underexplored in the field of bone biology. Considering agrin as a therapeutic target for bone formation and repair, our research group identified…
Several natural products have been investigated for therapeutic purposes, such as prevention and treatment of damages generated by metabolic disease. Fruits can be important sources of a plethora of bioactive compounds mainly concentrated in their peels. Jabuticaba peel extract (JPE) has been shown to be a promising product in the treatment of obesity, pre-diabetes, and liver complication…
(Only some records are available in English at this moment)
Pyle's disease is a rare skeletal disorder of long bone with wide metaphysis, increased trabecular bone, cortical thinning, and increased fragility fracture risk caused by a genetic deficiency in Secreted Frizzled Receptor Protein 4 (Sfrp4). In Sfrp4 null mice, cortical thinning is due to a deregulation of periosteal bone formation and endosteal remodeling mainly because activation of non…
Cell therapy using stem cells derived from different tissues of the body has been the subject of scientific investigations in the field of regenerative medicine as it is a promising alternative for the treatment of bone diseases. Among the types of stem cells, it is known that embryonic stem cells have a high plasticity and a great potential for self-renewal, which increases their ability…
The osseointegration of titanium (Ti) implants is based on bone remodeling, which involves a balance between bone tissue formation by osteoblasts and tissue resorption by osteoclasts. Our group has shown that a Ti surface with nanotopography obtained by chemical conditioning with H2SO4/H2O2 solution is capable of inducing osteoblast differentiation under both osteogenic and non-osteogenic…
Interactions between cells and titanium (Ti) are crucial for dental implant osseointegration. The integrins mediate adhesion of cells to extracellular matrix proteins and some members are involved in the process of osteoblast differentiation. Results of the project entitled "Role of Integrins on Osteoblast Differentiation of Mesenchymal Stem Cells Induced by Titanium Surfaces with Micro a…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 13 / 11 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 38 / 34 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 61 / 55 | All research grants and scholarships |
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