Graduate at Dentistry and master's at Periodontology at Paulista State Univerisity "Júlio de Mesquita Filho"- 2006 (Araraquara); PhD in 2010 in Bucco dental biology foccused on Molecular biology and Post doctoral in Epigenetics, 2013 at Campinas State University - UNICAMP. Nowadays is a researcher at Paulista University/UNIP and research fellow at Campinas State University - UNICAMP at Periodontology Department. Visitor fellow at University of Birmingham, Institute for biomedical Research - Cancer Sciences, Birmingham, United Kingdom. Has experience in molecular biology and cell culture, focusing on periodontal disease, regeneration, inflammation, genetics, epigenetics, DNA methylation and human mesenchymal stem cells. (Source: Lattes Curriculum)
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Despite the high occurrence of bone diseases and defects, the epigenetic background related to bone biology still represents a challenge. The results we have published so far highlight the individual epigenetic and transcriptional landscapes as strongly related to the acquisition of a specific osteogenic phenotype while the unpublished data recently obtained in our lab suggest the involve…
Multipotent periodontal ligament stem cells (PDLSCs) like other mesenchymal stem cells (MSCs) can give rise to bone, cartilage and fat tissues. They are relatively easily obtained during a third molar extraction and have been recently shown to have both good osteogenic potential and proliferation capacity. Therefore, they are promising candidates not only for periodontal regeneration but …
In the last few years, studies on the use of mesenchymal stem cells (MSCs) have brought promising results on regenerative therapy, although limited. Some boundaries relies on the fact that we have little knowledge about the basic biology of these cells, especially regarding epigenetic control landscape in the dedifferentiation and multipotentiality cellular state. Amongst several epigenet…
Multipotent periodontal ligament cells (PDLCs) have shown the ability to differentiate in some lineages, being good candidates for regenerative therapies. Our research group has characterized PDLCs presenting distinct osteogenic potentials, showing high (h-PDLCs) or low (l-PDLCs) capacity of mineral nodule formation, in vitro. Recently, amongst other genomic methodologies, these h- and l-…
Multipotent periodontal ligament cells (PDLCs) have shown the ability to differentiate in some lineages, being good candidates to regenerative therapies. Recently, our research group have characterized PDLCs presenting distinct osteogenic potentials, showing high (h-PDLCs) or low (l-PDLCs) capacity of mineral nodules formation, in vitro. These h- and l-DLCs were submitted to the Assay for…
Multipotent periodontal ligament stem cells (PDLSCs) have been recently shown to have both good osteogenic potential and proliferation capacity. Therefore, they are promising candidates not only for periodontal tissue repair but also for regenerative therapies in a broad range of bone diseases. However, they present different osteogenic potential. The molecular mechanism underlying osteog…
The scientific community has been focused on the research of human mesenchymal stem cells from periodontal ligament (PDLMSCs) because of its good accessibility, compared to other kinds of stem cells. Studies regarding its isolation and characterization have been growing in the last few years, although its basic biology is not completely understood, mainly regarding epigenetic regulation. …
(Only some records are available in English at this moment)
Since human multipotent periodontal ligament stem cells (hPDLSCs) can give rise to bone, they can be promising candidates for regenerative therapies in a broad range of bone diseases. However, hPDLSCs can show distinct osteogenic potential, which might be a clinical issue. The molecular mechanisms underlying their osteogenesis are not well understood, with limited information regarding th…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 12 | All research grants and scholarships |
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CV Lattes
ORCID