CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at bacharelado em quimica from Universidade de São Paulo (1987), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1992) and doctorate at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1995). Has experience in Chemistry, focusing on Inorganic Photochemistry, acting on the following subjects: complexos de metais de transição, espectroscopia eletrônica, fotosensibilização, fotoquimica and transferencia de eletrons. (Source: Lattes Curriculum)
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The aggregation processes of amyloid protein have implications in a number of diseases, including amyloid beta peptide (Ab) in Alzheimer's disease (AD) and insulin in type 2 diabetes. In addition to being costly chronic diseases included in the list of leading causes of death, several studies have indicated a close relationship between them, such as resistance to insulin, which is the rea…
The toxic oligomers of the b-amyloid (bA) peptide generated in the early stages of aggregation are primarily responsible for the synaptic loss of the CNS, causing cognitive changes in Alzheimer's disease (AD) patients. Due to their instability and structural heterogeneity, information on the structure, mechanism, and physiological effects of bA oligomers are not comprehensively known, hen…
This proposal solicits financial funds to acquire a FluoTime 100 spectrometer - Pico Quant, reactants, glassware, solvents, gas, and outsourced services. The grant will support research on the development of ruthenium(II) luminescent complexes to recognize and map in real time the modifications on the structure of the peptide b-amyloid (Ab) and Tau protein. Understanding how these metal …
(Only some records are available in English at this moment)
The aggregation processes of amyloid proteins in vivo are associated with the pathogenesis of several incurable neurologic diseases and in vitro they preclude or shows limitations both in storage and therapeutic applications such as on the biopharmaceutical protein insulin. However, stabilizing this conformation has disadvantages, since insulin is active in the monomeric form and dissocia…
Diabetes is a chronic progressive disease characterized by high blood glucose levels and associated with tissue and organ damage, therefore, access to affordable treatment, including insulin, is critical to the survival of people with diabetes. Insulin was the first biopharmaceutical produced on an industrial scale for the treatment of insulin-dependent diabetes. Insulin is an amyloid pro…
Type 2 Diabetes Mellitus (DM2) is a metabolic disease that reaches epidemic proportions worldwide. Insulin and amylin (amyloid polypeptide from human pancreatic islets (IAPP) are amyloid proteins secreted by pancreatic b cells. While insulin is associated with blood glycemic control, amylin has led to the development of DM2. Although several studies indicate that amylin toxicity comes fro…
(Only some records are available in English at this moment)
Photoinduced charge separation (CS) excited states are essential processes that occur in nature through the absorption of visible light by chlorophyll in the photosynthetic system generating molecular oxygen and glucose for plants. Due to the importance and scope of applications of these processes, several research groups have been dedicated to the synthesis of artificial molecules such a…
Our laboratory has been working on the development of luminescent complexes as teranostic agents for Alzheimer's disease. Recently, we prepared the luminescent complexes cis-[Ru(phen)2(Apy)]2+ (RuApy) in which phen = 1,10-phenanthroline and Apy = 4aminopyridine, 3,4-aminopyridine. For example, the complex containing the 3,4-Apy ligand is absorbed by neuronal cells reaching the cytoplasmic…
We have recently prepared the [Ru(phen)2(pPDIp)]2+ complex which is capable to mimic key features of the photosynthetic center (cumulative absorption of photons to separate charges by electron transfer) to promote challenging chemical. The interplay between the two chromophores Ru(II)-pPDIp coordination and p-p stacking of the pPDIp arrays in the dyad is markedly influenced by the medium …
(Only some records are available in English at this moment)
The neurotoxicity of oligomeric species of amyloid beta (OA²) peptide has been linked to damage caused to cell membranes by pore formation through interactions with cholesterol and ganglioside lipids. Consequently, studies of compounds that act directly on OA² at lipid membrane interfaces has enlarged considerably. Recently, we have demonstrated that the luminescent cis-[Ru(phen)2(3,4-Apy…
The design of organic-inorganic hybrid systems with near-infrared absorption and emission properties is attracting a great interest due to the variety of applications, including catalysis, medicine and luminescent sensing. An issue in planning organic-inorganic hybrid systems is the design of bridges to connect the different moieties and potentiate synergistic action. Following this strat…
Mitochondrias are organelles essentials for the life and death of the cell, participating of the cellular energy metabolism as well as in the control of programmed cell death. In this project we chose to develop mitochondria-targeted antioxidants because the respiratory chain is the major source of reactive oxygen species in vivo, and mitochondrial oxidative damage is the cause or lead …
In this project we intend to develop luminescent transition metals to act as photocatalysts for disinfection of water contaminated with pathogenic microorganisms. ¬The system was planned to work in rural and/or in small communities of poor sanitation, where lack of infrastructure, funding for operating expenses, plus the lack of training of users limit the use of conventional technologies…
The purpose of this project is develop luminescent Ru-Mn binuclear compounds, stable to thermal and photochemical reactions to mimetize the chemical step of natural photosynthesis. For this we have synthesized the complex [(phen)2Ru(phen)perylene(phen)-Mn(CO)3Br] where phen = 1,10- phenanthroline. The complex prepared shows intense luminescence in the visible region, is stable both therma…
| 6 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 20 / 13 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 37 / 29 | All research grants and scholarships |
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