Thiago Aparecido da Silva in research grants and scholarships supported by FAPESP.
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Invasive fungal infections (IFIs) show mortality at similar and higher levels compared to tuberculosis and malaria. Regarding neglected diseases, IFIs have a low financial support while tuberculosis and malaria are better supported. Since IFIs, candidiasis, aspergilosis, criptococosis and histoplasmosis have more effect on the global public health. The risk factors of IFIs are related to …
Chimeric Antigen Receptor (CAR) therapy is a new approach that utilizes bioengineering to modify immune cells so they are able to specifically target and kill pathogens or altered host immune cells (such as cancers). This approach involves generating modified cell surface molecules (chimeric receptors) and expressing these receptors in host immune cells. As these chimeric receptors recogn…
Invasive fungal infections are a serious public health problem that affects more than one billion people worldwide. A species of particular concern is Cryptococcus neoformans, which is responsible for most cases of fungal meningitis in immunocompromised patients. The annual death rate due to cryptococcosis is alarming, reaching around 625,000 deaths. C. neoformans has mechanisms that make…
Fungal infections commit millions of lives each year and the cryptococcosis has important relevance because affects immunocomprised and healt individuals. Cryptococcosis representing one of the main causes of worldwide morbidity and mortality among HIV+ individuals. The advance in the development of new antifungal drugs against human cryptococcosis is outdated when considering the ability…
Invasive Candidiasis is an infection caused mainly by Candida albicans and is often associated with high rates of mortality. Candida infections affect 80% of the patients among all fungal infections in hospitals and, in Brazil, the incidence of Candidemia is approximately 2.5 cases in 1000 hospital admissions. Controlling Invasive Fungal Infections (IFIs) depends strongly on the innate im…
Paracoccidioidomycosis (PMC), caused mainly by the fungus Paracoccidioides brasiliensis, is a systemic granulomatous mycosis of higher prevalence in South America with high correlation with individuals having rural activities. PMC caused about 51% of deaths caused by systemic mycoses in Brazil between the years 1996 and 2006, according to data from the Ministry of Health. The infection oc…
Paracoccidioides brasiliensis is a pathogenic fungus belonging to the genus Paracoccidioides that has a restricted location a Latin America with the highest occurrence of cases in Brazil, Colombia and Venezuela. It is dimorphic and presents the carbohydrate ±-1,3-glucan, a virulence factor that compromises the recognition of the fungus by cells of innate immunity through pattern recogniti…
Cryptococcus gattii is an enveloped yeast that belongs to the genus Cryptococcus remains one of the leading causes of criptococose in humans by inhalation of the propagules. The infection is persistent on respiratory tissues of immunocompromised individuals, but can also progress to meningoencephalitis and disseminate to other tissues. The C. gattii is an endemic pathogen classically loca…
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T cell interaction with antigen presenting cell (APC), in which T-cell receptor (TCR) recognizes peptide-MHC complexes (p-MHC), is required to recruit downstream signaling molecules and trigger T cell activation. It was recently demonstrated that chimeric antigen receptor (CAR) expressed on T cells recognizes proteins, glycoproteins, and glycolipids as potential targets on cells surface, …
| 1 / 1 | Ongoing research grants |
| 3 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 25 / 23 | All research grants and scholarships |
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