Graduated in Biochemistry from Facultad de Farmacia y Bioquímica from Universidad de Buenos Aires (UBA), Argentina (2003). PhD from the Department of Microbiology, Immunology and Parasitology at the Universidade Federal de São Paulo (UNIFESP), studying the control of mRNA translation in neurons (2011). During his doctorate, he did an internship in Dr. Nahum Sonenberg's laboratory at McGill University in Montreal, Canada (2010). He held a post-doctorate at the A.C.Camargo Cancer Center (2015). He is currently Researcher II at the A.C.Camargo Cancer Center, São Paulo, and Advisor to the Graduate Program in Oncology at the Fundação Antônio Prudente. He is interested in studying changes in signaling pathways in tumors, with an emphasis on those that control the translation of mRNAs. He is currently developing the CRISPR/Cas9 technique for the generation of cell models for the study of signaling pathways and the effect of cancer-related mutations. (Source: Lattes Curriculum)
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Brain tumours, particularly glioblastoma (G8M), have limited therapeutic options. New therapies are needed against this almost universally fatal cancer. In recent years, scientists have developed approaches that involve the use of common viruses to reactivate the immune system within patients to enable it to recognize and eliminate cancer cells. The laboratory of Dr. Alain at University o…
The RSKs (RSK1-4) are a family of kinases directly regulated by the Ras-ERK1/2 pathway. The RSKs have been involved in the control of different functions, such as proliferation and the control of transcription and mRNA translation, in several types of tumors. However, we previously described that two widely-used RSK inhibitors (SL0101 and BI-D1870) are nonspecific, and thus, functions pre…
At the A.C.Camargo Cancer Center (ACCCC) we often come across rare or undescribed gene mutations/alterations that could be associated with tumor development in patients. A variant of uncertain (unknown) significance (VUS) is a variation in a genetic sequence for which the association with disease risk is unclear, posing a major challenge for genetic counseling and clinical management of t…
TP53 (p53) is a tumor suppressor whose functions and mutations are widely studied. TP53 germinative mutations can lead to Li-Fraumeni syndrome (LFS), which is characterized by the development of tumors in multiple organs at an early age. The R337H substitution (TP53R337H) in the oligomerization domain impairs the formation of tetramers, necessary for the correct function of TP53. The few …
RSK are a group of kinases of the ribosomal protein s6 kinase family consisting of four isoforms (RSK1-4) and are regulated via the Ras-ERK1/2 pathway. In the literature, this group of kinases was associated with functions essential for the survival and development of tumors through the control of transcription, translation and proliferation, among other functions. However, studies of our…
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| 2 / 2 | Completed research grants |
| 6 / 5 | Completed scholarships in Brazil |
| 8 / 7 | All research grants and scholarships |
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