CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Com Habilitação Em Biologia from Universidade Presbiteriana Mackenzie (1991), master's at Immunology from Universidade de São Paulo (1995) and PhD at Immunology from Universidade de São Paulo (1999). Scientific Researcher at Butantan Institute in Immunopathology Laboratory. Has experience in Immunology, focusing on Immunoregulation, acting on the following subjects: cellular immunology, antibody production, dendritic cells and immune response elicited by venoms and isolated toxins from animals. (Source: Lattes Curriculum)
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Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
Animal venoms have been studied aiming to elucidate the pathophysiology of the envenomation as well as the identification of the molecules with therapeutic potential. The envenomation by Crotalus durissus terrificus rattlesnake, unlike those induced by many others snakes, is characterized by discrete local reaction and pronunciated systemic effects. It has been shown that the main toxin (…
The characterization of the mechanisms involved in the immunomodulation exerted by distinct molecules is relevant to the development of new therapeutic agents. Secretory/excretory products from helminth are able to suppress the immune system to ensure its survival in the host. Our results showed that glycosylated high molecular weight antigens from Ascaris suum extract inhibit the dendrit…
The identification/characterization of immunomodulatory molecules as well the mechanisms involved in their effect have been the focus of numerous studies, since they may represent alternative tools in the treatment of diseases or immunological disorders as autoimmune diseases, chronic inflammation among others. Helminth infections as Ascaris suum (Asc) and their secreted antigens induce a…
(Only some records are available in English at this moment)
Secretory/excretory products from helminths exert a suppressive effect on the immune system, ensuring its survival in the host. High molecular weight components from Ascaris suum extract (PI) directly modulate the dendritic cells (DCs) maturation, inhibiting the expression of costimulatory and MHC-II molecules and consequent lymphocytes T proliferation. This PI effect on DCs is independen…
The Bothrops are responsible for about 80 % of reported accidents in Brazil. Bothrops poisoning are described in several places and among these effects is the tissue damage that can result in dysfunction of the affected organ. Two toxins, jararhagin (JAR) and bothropstoxin - I (BthTX - I), isolated from Bothrops jararaca and Bothrops jararacussu, respectively, are involved in intense infl…
Mechanisms of immune tolerance are related to mucosal protection against pathogens or antigens from the intestinal microbiota. When failure occurs in the regulation of immune system diseases may arise as the intestinal inflammation. Crohn's disease and ulcerative colitis are the main examples of these pathologies causing rectal bleeding, severe diarrhea, abdominal pain, fever, fatigue and…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 11 / 5 | Completed scholarships in Brazil |
| 19 / 12 | All research grants and scholarships |
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