CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Biological Sciences (2010 and 2011), and PhD in Sciences from Universidade Federal de São Paulo (2016), with a postdoctoral degree in the DNA Repair Laboratory of the Institute of Biomedical Sciences of the University of São Paulo (2022). He has experience abroad, working as a visiting researcher at the Instituto di Endocrinologia ed Oncologia Sperimentale (IEOS) del Consiglio Nazionale delle Ricerche (CNR) at the Università degli Studi di Napoli Federico II, Naples, Italy. in Naples, Italy and at the Institut für Toxikologie at the Universitätsmedizin Mainz of the Johannes Gutenberg-Universität Mainz, Mainz, Germany. His works are concentrated in the areas of Genetics, with emphasis on Human and Medical Genetics, Molecular Biology and Biochemistry, working with projects of molecular and clinical characterization of Squamous Carcinoma of the Oral Cavity and Oropharynx, Thyroid Carcinomas and Gliomas. He is currently a substitute professor of Biochemistry and Molecular Biology at Universidade Federal São Paulo, Campus Diadema (UNIFESP). (Source: Lattes Curriculum)
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Patients with glioblastoma, the most common type of malignant neoplasm of the brain in adults, still show poor prognoses with the available therapeutic protocols, and Temozolomide (TMZ) is the main drug used to treat this type of tumor. TMZ is an alkylating agent that causes DNA methylation and a wide range of DNA damage (genomic and mitochondrial), leading to cell death. However, tumors …
The Papillary Thyroid Carcinoma (PTC) is the most common histological subtype of thyroid tumors. Alterations in genes coding for the MAPK pathway plays a crucial role in its pathogenesis, and mutations in the BRAF and RAS oncogenes and rearrangements involving the RET oncogene are the most frequent. The recognition of these alterations and the association studies can lead to the most effi…
Temozolomide (TMZ) is the main drug used to treat gliomas, which causes DNA damage leading to cell death mainly as a consequence of processing of the primary damage O6-methylguanine (O6meG). Several mechanisms of resistance were described, and the ability of MGMT (O-6-methylguanine-DNA methyltransferase) to directly reverse O6meG in the DNA molecule is the most significant. Moreover, the …
Genetic alterations play a crucial role in pathogenesis, diagnosis and treatment of thyroid tumors. The Papillary Thyroid Carcinoma is the most prevalent subtype, and mutations in BRAF and RAS oncogenes and rearrangements involving the RET oncogene are the most frequent. Our group investigated the prevalence of RET/PTC rearrangements and BRAF V600E mutation in a series of CPT (n = 118) an…
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 5 / 5 | All Scholarships |
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