Graduated in Biological Sciences at Institute of Biosciences, University of São Paulo (1998), PhD in Biology and Genetics at University of São Paulo (2003) and post-doctorate in biotechnology from Instituto Butantan (2004). Currently, a Scientific Researcher at the Butantan Institute and director of the Applied Toxinology Laboratory. Experience in genomics, transcriptomics and molecular biology in general, with an emphasis on large-scale DNA sequencing methods. Acting mainly on the following topics: omics investigation of animal venoms and their effects, evolution of snake venoms, rear-fanged snakes and biochemical characterization of animal toxins. (Source: Lattes Curriculum)
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Advanced snakes (superfamily Colubroidea) constitute one of the most diverse groups of terrestrial vertebrates worldwide. It is comprised of more than 2,500 species and includes the front-fanged venomous families Viperidae (e.g., vipers) and Elapidae (e.g., coral snakes), and rear-fanged venomous species in the family Colubridae (e.g., colubrids). In the Neotropical region, where their di…
This project will determine how secondary key innovations within the venom system contribute to diversification patterns in the advanced snakes and test for biases in the genetic pathways underlying rapid phenotypie evolution in venoms as a means for understanding the mechanism underlying the process of diversification in this diverse group. In the first part, we will test for relationshi…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Venom proteins produced by snakes in the family Viperidae are one of the most widely-studied types of animal toxins. The goal of a recently initiated (2012) collaboration between researchers at Ohio State (Gibbs) and the Instituto Butantan in São Paulo (I. Junqueira de Azendo) is to use novel genomic approaches to identify the evolutionary causes of variation in snake venom composition in…
Most of the studies on snake venoms relied on traditional biochemistry and molecular biology approaches, contributing to several fields of biological sciences, such as pharmacology, immunology and evolutionary biology. The global characterization technics, such as proteomics and transcriptomics, improved this achievements by suggesting the complex gene organization of most toxin families …
(Only some records are available in English at this moment)
Advanced snakes developed a specialized toxin-producing maxillary gland, enabling them to inoculate toxins into their preys. This gave them an advantage over other predators and allowed for their trophic niche diversification. Among the wide spectrum of snake diversity in the neotropics, the family Dipsadidae harbors the highest amount of species. Among them, we found venomous and non-ven…
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
Differences in venom composition produced by snake species can result from distinct regulatory mechanisms acting in each species. However, comparative analysis among snake species focusing on identifying regulatory regions and elements that led to distinct venom composition are still scarce. Among venomous snakes, Agkistrodon piscivorus may represent an ideal model to test complement our …
Elapids are a group of venomous snakes for which the morphology of the cephalic glands is littleknown. The few studies involving these snakes focus on the morphology of venom glands, which arethe most studied cephalic glands among vertebrates. However, preliminary results have shown thatmicrurine snakes have an inferior rictal gland, a virtually unknown gland in elapids composedexclusivel…
The analysis of molecular evolution of snake toxins performed so far generally lacks basic genomic information as background. Duplications, insertions and intron deletions appears to be more important than random point mutations for the diversification of the snake venom metalloproteinase (SVMP), as recently described on Echis ocellatus genes. In this sense, we proposed in this posdoc to …
| 3 / 3 | Ongoing research grants |
| 7 / 4 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 32 / 18 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 51 / 34 | All research grants and scholarships |
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CV Lattes
ORCID