Catarina Segreti Porto

• Abstract

  Prostate cancer initially responds well to androgen-deprivation therapies, but the majority of tumors evolve from an androgen-sensitive to an androgen-independent form of the disease, also known as castration-resistant prostate cancer (CRPC), which presents a poor prognosis and no effective therapy. Recent studies from our laboratory have shown the expression and the extranuclear localiza…

  Estrogen receptors and galectin-3 in androgen-independent prostate cancer cells, AP.R

• Abstract

  Prostate cancer initially responds well to androgen-deprivation therapies, but the majority of tumors evolve from an androgen-sensitive to an androgen-independent form of the disease, also known to castration-resistant prostate cancer (CRPC). The molecular mechanisms involved are still not well understood. The androgen-independent prostate cancer cell lines PC-3, derived from a bone metas…

  Intracellular signaling and role of the estrogen receptors in androgen-independent prostate cancer and testicular cancer cells., AP.R

• Abstract

  Testicular cancer has the one of the highest cure rates among all cancer. However, it has been observed, in addition to male infertility, the resistance to treatment in 30% of the patients with metastatic non-seminoma testicular cancer. There are many genes and signaling pathways associated with testicular cancer. Estrogens, their receptors (ESR1 and ESR2) and signaling pathways may play …

  Estrogen receptors and intracellular signaling pathways involved in the regulation of cell proliferation of testicular cancer and castration-resistant prostate cancer, AP.R

(Only some records are available in English at this moment)

• Abstract

  Dynamic changes in the expression of estrogen receptors have been shown with the progression of prostate cancer. Studies have shown that in the early stages of prostatic carcinoma, the genes encoding the ESR1 and ESR2 estrogen receptors are silenced, occurring low expression of these receptors in tumors confined on prostate. However, ESR1 reappears with cancer progression and, in the meta…

  Regulation of the transcription factor KLF-4 in androgen independent prostate cancer cells PC-3 by activation of estrogen receptors, BP.IC

• Abstract

  Direct and indirect effects of estrogen have been shown in the development and homeostasis of the prostate tissue and in the etiology of prostatic diseases. However, the role of this hormone in the development of castration-resistant prostate cancer (CRPC) is not well established. Estrogen can act via the classical receptors ESR1 (ERalpha) and ESR2 (ERbeta), located predominantly in epith…

  Expression, regulation and function of estrogen receptors in androgen-independent prostate cancer cells PC-3, BP.MS

• Abstract

  Testicular germ cell tumors type II are classified into two main categories: seminoma and nonseminoma (including embryonal carcinoma), both derived from common precursor cell type called carcinoma in situ. The dormancy period of these tumors until puberty suggests a hormone-dependent mechanism for development or progression of the tumor. Estrogen could play a role in this process. In semi…

  Effects of 17beta-estradiol and their receptors in cells of testicular cancer, BP.PD

(Only some records are available in English at this moment)