Silvia Regina Caminada de Toledo

• Abstract

  Gliomas are epithelial tumors derived mainly from astrocytes. The low-grade tumors comprise the majority of these cancers in children, while high-grade, especially glioblastoma multiforme, are prevalent in adults. Little is known about the molecular characteristics of low-grade gliomas of childhood, and the genetic alterations observed frequently in adult tumors are rarely found in this a…

  Prognostic markers investigation in brain tumors most frequenttly in childhood and adolescents: pilocytic astrocytoma and medulloblastoma, AP.R

• Abstract

  Sarcomas are a heterogeneous group of malignant tumors with a high frequency in children. From a genetic standpoint, sarcomas can be divided into two main groups, which are distinguishable by cytogenetic findings. One group is characterized by the presence of simple karyotypes, near diploid, with a few specific chromosomal changes, which include the rhabdomyosarcoma (RMS), Ewing's sarcoma…

  Molecular e functional characterization of bone and soft tissue sarcomas of children and adolescents, AP.R

• Abstract

  Osteosarcoma (OS) is malignant bone tumor derived from primitive mesenchyme with a high incidence peak among children and adolescents, during the second decade of life. It is known that the OS is the most common primary neoplasia of the bone and that it has a high risk of metastasis, the lung being the most common site. A second group of patients, who are rarer, includes children under 10…

  Osteosarcoma in children under 10 years old: a genetic investigation to assist in the determination of prognosis and therapeutic orientation, BP.MS

• Abstract

  Central nervous system (CNS) tumors represent the most common tumors in childhood and adolescence and neuroepithelial tumors are the most frequent, which includes ependymomas (EPN) and gliomas. The ability to analyze tissues on a genomic scale has changed the understanding of childhood and adolescence CNS tumors, as until recently they were seen only as unique identities. These tumors sta…

  Investigation of genetic alterations of childhood and adolescence ependymomas and gliomas using the new generation sequencing strategy, BP.MS

• Abstract

  Central Nervous System (CNS) tumors in children represent the most common neoplasia of childhood and adolescence. The ability to analyze tissues on a genomic scale modified the understanding of these tumors and allowed the identification of several subgroups. According to the new classification of brain tumors, established by the World Health Organization, the diagnosis is based on the hi…

  The cerebral cortex size controlling gene, ASPM, gene expression in childhood and adolescence brain tumors, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Osteosarcoma is the most common primary malignant bone tumor affecting children, adolescents and young adults. Patients with localized disease are cured in 65% of patients, but no improvement in prognosis has been seen since the addition of chemotherapy 40 years ago. In order to better understand the biology of osteosarcoma and to develop novel immunotherapies, we propose to use the lates…

  Understanding the tumor microenvironment of osteosarcoma, BE.EP.DR

• Abstract

  Cancer is a genetic disease driven by somatically acquired point mutations. Osteosarcoma is the most common primary bone malignancy with a particularly high incidence in children and adolescents. Unlike many sarcomas, which are defined by specific chromosomal translocations, osteosarcoma is characterized by complex genomic alterations and high level heterogeneity. The mainstay of osteosar…

  Determining the clinical impact of genetic alterations in osteosarcoma, BE.EP.PD