graduate at Farmácia from Universidade de São Paulo (1982), master's at Pharmacology from Universidade Estadual de Campinas (1997) and ph.d. at Pharmacology from Universidade Estadual de Campinas (2001). Has experience in Pharmacology, acting on the following subjects: bothrops jararacussu, junção neuromuscular, plantas medicinais, myotoxicity and crotoxin. (Source: Lattes Curriculum)
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A serious complication to poisoning caused by venomous snakes (Bothrops and Crotalus) is the Acute Kidney Injury (AKI). The prevention of AKI should be attempted in all patients envenomed by venomous animal by early administration of specific antivenom treatment of hypotension, shock and maintaining an adequate state of hydration. On the other hand, phytochemicals as tanin/tannic acid sho…
Many natural products influence neurotransmission and are used clinically. In particular, facilitatory agents can enhance neurotransmission and are potentially useful for treating neuromuscular diseases in which muscular weakness is the major symptom. In this work, we investigated the facilitatory effect of apolar to polar fractions of Casearia sylvestris Sw. (guaçatonga) on contractility…
Traditional medicine of Brazilian central savannah preconizes Dipteryx alata extracts against snakebites venoms. Previous studies have shown the extract of this plant's bark antagonizing the neuromuscular blockade caused by snake venom in isolated mice diaphragm and phrenic nerve models. In the present study, the triterpenoids lupeol, lupenone, 28-OH-lupenone and betulin, which are consti…
(Only some records are available in English at this moment)
The World Health Organization (WHO) estimates that 5.4 million people are annually affected in accidents with venomous snakes, and approximately one tenth of cases come to death or remain permanently deformed, which make these accidents a global public health problem. The search for alternatives that minimize the seriousness of the snake accident is growing, especially in natural sources …
The use of gold in medicine mainly in cancer diagnosis and therapies has led to other biological applications, in the form of gold nanoparticles (AuNPs), to act as a drug delivery agent, in contrast in computed tomography, produce bioimages and aid in gene therapy, thanks to its size and properties. Metallic nanoparticles have been investigated against the toxic effects of snake venoms. I…
Cannabis sativa is used worldwide for recreational purposes due to its psychotropic properties induced by 9-tetrahydrocannabinol (THC). The plant contains several compounds among them, the cannabidiol (CBD), which has been a matter of investigation in diseases which affect the central nervous system such as epilepsy, schizophrenia, Parkinson's, and Alzheimer's diseases. The presence of C…
The snake venom contains a multitude of substances with simple and complex structures, whose proportion and individual characteristics vary with the species. From the epidemiological point of view, the World Health Organization (WHO) estimates that 5.4 million of people are bitten by snakes each year in the world, becoming a global health problem. The search for alternatives that minimize…
Pesticides are used both at home and in agriculture to combat pests. However, its toxic effects are not limited only to organisms that cause damage to crops, but also affect soil, water, air and other organisms that initially would not be their target. Among pesticides, organophosphates (OFs) including chlorpyrifos, are among the most used, their mechanism of action being the inhibition o…
(Only some records are available in English at this moment)
Previously our study with barks hydroalcoholic extract from Dipteryx alata Vogel showed an antiophidian property against the neuromuscular blockade induced by Bothrops jararacussu snake venom. Our objectives are: 1) To obtain extracts of different polarities (hexane, dichloromethane, ethyl acetate and methanol) from barks of D. alata; 2) To identify the extract responsible by antineurotox…
| 14 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 13 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 30 / 15 | All research grants and scholarships |
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CV Lattes
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