Ana Paula de Melo Loureiro

• Abstract

  There is a need to understand how metabolic alterations can contribute to modulating the activity of signaling pathways, transcription factors and epigenetic marks that promote cell proliferation, which may have implications for cancer prevention and treatment.Benzo[a]pyrene (B[a]P) is a carcinogen widespread in the environment and is used in our studies to induce malignant transformation…

  Modulation of DNA adducts, metabolism, and epigenetic marks in cultured normal human cells supplemented with benz[a]pyrene, NAD+, succinate and/or fumarate: implications to tumorigenesis, AP.R

• Abstract

  Diabetes mellitus is considered a serious global health problem, and its complications have a major impact on population mortality. Diabetic nephropathy is a major complication of metabolic disease, characterized primarily by a progressive decline in the rate of glomerular filtration, persistent proteinuria, and hypertension. Several mechanisms have been proposed as important in the patho…

  The role of metabolic memory in the development of diabetic nephropathy, AP.R

• Abstract

  Bisphenol A (BPA) is largely used for plastic production and widely distributed in the environment, which favors chronic human exposure to this xenobiotic since the intrauterine stage. There is great concern about increased risk of development of different types of cancer by BPA exposure, being that four modes of BPA action are considered to contribute to this increase: endocrine estrogen…

  Characterization of a new biotransformation pathway of bisphenol A and quantitation of DNA lesions in HL-60 and MCF-7 cells, AP.R

(Only some records are available in English at this moment)

• Abstract

  Important advances in the treatment of cancer may arise from a better understanding of the molecular origins of the disease and changes underlying cell transformation and proliferation of pre-neoplastic cells. Lung cancer is among the commonest types and is often associated with smoking, being responsible for high mortality rates. In studies of our group, benzo[a]pyrene (B[a]P), a carcino…

  Modulation of NAD+ intracellular concentration and its effect in the tumorigenesis induced by benzo[a]pyrene in human bronchial epithelial cells, BP.DD

• Abstract

  Diabetes mellitus is a complex metabolic syndrome characterized by a deficiency of insulin or resistance development to this hormone, leading to hyperglycemia and altered metabolism of glucose, lipids and proteins. It is considered a serious global health problem, and its complications are the major causes of morbidity and mortality in patients with the disease. From the standpoint of th…

  Oxidative damage and tubular injury markers in an experimental diabetic nephropathy model, BP.IC

• Abstract

  Diabetes mellitus is considered a serious global health problem, and its complications have a major impact on population mortality. Diabetic nephropathy is a major complication of metabolic disease, characterized primarily by a progressive decline in the rate of glomerular filtration, persistent proteinuria, and hypertension. Several mechanisms have been proposed as important in the patho…

  Variables on glycemic control and pathogenesis of diabetic nephropathy: research on the phenomenon of metabolic memory, BP.DD

(Only some records are available in English at this moment)