graduation at Medicina from Universidade Estadual de Campinas (2000) and doctorate at Neurologia from Universidade Estadual de Campinas (2008). Has experience in Medicine, focusing on Medicine, acting on the following subjects: cefaléia trigêmino-autonômica and pupila de argyll robertson. (Source: Lattes Curriculum)
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Alzheimer´s disease (AD) is the most common neurodegenerative disorder and its prevalence is increasing mainly due to the aging of the population. Recent clinical trials with anti-amyloid and other drugs in AD dementia and Mild Cognitive Impairment (MCI) have failed, and one possible explanation is that diagnosis is made too late, when subjects have already relevant clinical symptoms. Thu…
The central biological questions of our RIDC is the investigation of basic mechanisms that lead to epilepsy and stroke and the injury mechanisms that follow the disease onset and progression, and are related to prevention, treatment and rehabilitation. Our goals are to develop new methods and techniques to improve the understanding of mechanisms of damage, plasticity and repair in epileps…
Alzheimer's disease (AD) is among the most prevalent clinical conditions, mostly due to the population ageing. Also, among the most prevalent diseases, AD is the only which does not have effective prevention and treatment. One of the most relevant aspects in AD research is the development of biomarkers to characterize this disease in its earlier stage, aiming a better pharmacological mana…
Mild cognitive impairment (MCI) refers to the diagnostic term applied to individuals who arebetween preserved cognitive function and dementia, which may be a precondition for thedevelopment of Alzheimer's disease (AD). Due to the predicted increase in the incidence ofAD, the importance of obtaining an early diagnosis and intervening with easily accessible toolsis highlighted to reduce inv…
Population ageing is a global trend and a risk factor for dementias. Therefore, this sindrome occurrence is increasing around the world and Alzheimer's Disease (AD) is the most prevalent one between them. Pathophysiologically, Alzheimer's Disease can be characterized by the presence of b-amyloid plaques on cerebral cortex and neurofibrillary tangles, biomarkers that can be measured by cer…
Suspected Non-Alzheimer Pathophysiology (SNAP) is a biomarker-based concept whose underlying pathological causes have not yet been understood. It refers to individuals with negative levels of B-amyloid biomarkers, but in whom biomarkers of neurodegeneration and/or p-Tau are positive. SNAP causes great interest in research, as it is unclear whether it should be considered an independent cl…
Alzheimer's disease (AD) is a neurodegenerative condition of relevant social and economicimpacts and its early diagnosis is essential to improve the prognosis of patients. Thus, theseeking for promising new techniques in the investigation of early markers of the disease is ofparamount importance. In this paper, a relatively new technique will be applied in the study ofAD alterations, an a…
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The goal of this proposal is to develop a CSF assay to detect N-terminal caspase-6 (Casp6)-truncated tau (tr-tau) and measure levels of this biomarker in Alzheimer's disease (AD) and other tauopathies. Neurofibrillary tangles (NFT), formed by the intraneuronal deposition of tau, are one of the pathological hallmarks of AD. The mechanisms involved in the early pathological processing of ta…
Alzheimer's disease (AD) dementia is a neurodegenerative disease characterized by progressive brain atrophy and cognitive decline. Although AD is defined by the excessive amount of neuritic plaques and neurofibrillary tangles, the complete neurodegenerative process is much more complex and not fully understood. The most accepted models of AD progression indicate that pathophysiological ch…
Alzheimer's disease (AD) is a degenerative disorder that causes cognitive impairment and dependence in activities of daily life. Amnestic Mild Cognitive Impairment (aMCI) is a term used to diagnose patients with clinical decline in memory and with or without more cognitive domains, but with normal social and functional performance. These patients have a greater chance of developing AD. Ar…
Recent research in the Alzheimer's disease (AD) neuroimaging field has moved beyond regional alterations, raising the concept of dysfunctionality of brain networks to explain the cognitive and clinical symptoms of AD patients. Amongst all networks investigated in the AD field, the Default Mode Network (DMN) is undoubtedly the most studied, and several studies show a breakdown in its funct…
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 18 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 29 / 28 | All research grants and scholarships |
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CV Lattes
ORCID