Soraia Katia Pereira Costa

• 50th Brazilian Congress of Pharmacology and Experimental Therapeutics (SBFTE), AO.R

• Abstract

  Pruritus or itching, as pain, is a sensory experience similarly aversive associated with the desire to scratch. However, unlike the pain, there is a great lack of studies that explore the stimuli or mechanisms of action capable of inducing the perception of pruritus/itching. The current therapy for this symptom limited to the class of anti-histamine drugs, which acts not always satisfacto…

  Bioavailability of Hydrogen Sulfide in a topical nanoformulation in experimental psoriasis, AP.R

• Abstract

  Itching, similar to pain, is an unpleasant sensory sensation associated with the desire to scratch. In contrast to pain, there is a great lack of studies that investigate the mechanisms of action involved in the perception of itch. Currently, the available therapy is restricted to anti-histamines, although not always satisfactory for some forms of itching, such as those common in skin dis…

  Pharmacological evaluation of sulfide hydrogen donors (rapid and slow release) in pruritus and related inflammation in mice skin, AP.R

(Only some records are available in English at this moment)

• Abstract

  Interstitial Cystitis or Bladder Pain Syndrome (IC/BPS) is a chronic painful inflammatory disease, which affects 2-17% of the world population, and is characterized by pelvic pressure, voiding urgency and frequency. Although the mechanisms that leads to its development are not well established, it is known that both the expression of the subunits of the soluble Guanylate Cyclase enzyme (s…

  Modulation of soluble guanylate cyclase-cyclic guanosine monophosphate (sGC-cGMP) pathway by hydrogen sulphide (H2S) in experimental Cystitis, BP.DD

• Abstract

  Psoriasis is a chronic inflammatory disease, immune-mediated, with 2-4% of global incidence. Characterized mainly by skin lesions associated with intense itching, which greatly reduces the life quality of patients. Neither the classic anti-inflammatory steroid therapy nor biological agents is always effective, besides the high cost and serious adverse effects, as well as works efficiently…

  Pharmacological evaluation of a microemulsion containing an slow release donor of H2S (GYY4137) in an experimental model of psoriasis, BP.MS

• Abstract

  We have previously shown that early exposure to 1,2-naphthoquinone (1,2-NQ) might sensitizes the oxidative system of male, thus leading to an increase in inflammatory response in male but not in female juvenile mice. By comparison, environmental pollutants and reactive species activate TRPA1 channels, that are expressed in bronchopulmonary C-fibre terminals, thus suggesting that these rec…

  Role of TRPA1 receptors in the distinct susceptibility to lung allergic inflammation in both mice gender exposed to pollutant in neonatal phase, BP.DR

(Only some records are available in English at this moment)