Abstract
Sickle cell disease (SCD) is caused by a single base substitution in codon 6 (GAG/GTC ) of the beta globin gene, leading to production of hemoglobin S. The fundamental event in the pathogenesis of sickle cell anemia (SCA ) is the polymerization of HbS . Currently it is widely accepted that leukocytes also play an important role in the pathophysiology of the disease, adhering to the endot…